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Publications

Journal Article Ppublish

PubMed: 41886570 DOI: 10.1126/science.adw9761

Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito.

Science 391(6792):1373-1378

Authors: Jacob A Tennessen, Raphael Brosula, Estelle Chabanol, Sara Bickersmith, Angela M Early, Margaret Laws, Katrina A Kelley, Maria Eugenia Grillet, Dionicia Gamboa, Eric R Lucas, Jean-Bernard Duchemin, Martha L QuiƱones, Maria Anice Mureb Sallum, Eduardo S Bergo, Jorge E Moreno, Sanjay Nagi, Nicholas J Arisco, Mohini Sooklall, Reza Niles-Robin, Marcia C Castro, Horace Cox, Mathilde Gendrin, Jan E Conn, Daniel E Neafsey

Affiliations

  • Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Institut Pasteur de la Guyane, Cayenne, French Guiana.
  • New York State Department of Health, Wadsworth Center, Albany, NY, USA.
  • Instituto de ZoologĆ­a y EcologĆ­a Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela.
  • Laboratorio de Malaria: ParĆ”sitos y Vectores, Laboratorios de InvestigaciĆ³n y Desarrollo, Facultad de Ciencias e IngenierĆ­a, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Liverpool School of Tropical Medicine, Liverpool, UK.
  • Arboviruses and Insect Vectors, Institut Pasteur, Paris, France.
  • Universidad Nacional de Colombia, BogotĆ”, Colombia.
  • Faculdade de SaĆŗde PĆŗblica, Universidade de SĆ£o Paulo, SĆ£o Paulo, Brazil.
  • Instituto Pasteur de SĆ£o Paulo, SĆ£o Paulo, Brazil.
  • Instituto de Altos Estudios Dr. Arnoldo GabaldĆ³n, Centro de Investigaciones de Campo Francesco Vitanza, Bolivar, Venezuela.
  • Vector Control Services, Ministry of Health, Georgetown, Guyana.
  • Department of Biomedical Sciences, College of Integrated Health Sciences, State University of New York at Albany, Albany, NY, USA.

Abstract

Malaria in South America remains a serious public health problem. Anopheles (Nyssorhynchus) darlingi is the most important malaria vector across tropical Latin America. Vector-targeted disease control efforts require a thorough understanding of mosquito demographic and evolutionary patterns. We present and analyze whole genomes of 1094 An. darlingi (median depth 18x) from six South American countries. We observe deep geographic population structure, high genetic diversity including 13 putative segregating inversions, and no evidence for sympatric cryptic taxa despite high interpopulation divergence. Strong signals of selection are plausibly driven by insecticides, especially on cytochrome P450 genes. Our results will facilitate effective mosquito surveillance and control while highlighting ongoing challenges that a diverse vector poses for malaria elimination in the Western hemisphere.

MeSH

Malaria, Genomics, Metagenomics, Mosquito Vectors