Journal Article Review Ahead of print
PubMed: 41895071 DOI: 10.1016/j.pharmr.2026.100116
Adhesion G protein-coupled receptors.
Pharmacol Rev 78(3):100116
Authors: Tobias Langenhan, Garret R Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea de Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser … and 33 other authors
Affiliations
- Rudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany; Comprehensive Cancer Center Central Germany (CCCG), Leipzig, Germany; Faculty of Life Sciences, Institute of Biology, Leipzig University, Leipzig, Germany.
- Department of Molecular, Cell, and Systems Biology, University of California Riverside, Riverside, California.
- Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois.
- Research Laboratories, Department of Orthopedics, Trauma and Plastic Surgery, Medical Faculty, Leipzig University, Leipzig, Germany; Research Laboratories, Department of Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Faculty, Leipzig University, Leipzig, Germany.
- Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
- Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
- Interfaculty Institute of Bioengineering and Ludwig Institute for Cancer Research Lausanne, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
- Rudolf Schönheimer Institute of Biochemistry, Signal Transduction, Medical Faculty, Leipzig University, Leipzig, Germany; Department of Translational Drug Research and Signal Transduction, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
- Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.
- Rudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
- Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Mexico City, Mexico.
- Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado; Department of Medicine, Division of Pulmonary Sciences and Critical Care, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
- Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California.
- Laboratory of Molecular Neurooncology, Department of Neurosurgery, O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
- Department of Biomedical Sciences, Institute of Neurosciences (IDIBAPS), University of Barcelona, Barcelona, Spain.
- Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas.
- Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Cardiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
- Division of Structural Studies, MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Oncology, University of Cambridge, Cambridge, UK; Department of Oncology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
- Department of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, Hatfield, UK.
- Department of Physics and Mechanobiology Institute, National University of Singapore, Singapore, Singapore.
- Department of Molecular and Cell Biology, University of California, Berkeley, California; Howard Hughes Medical Institute, Chevy Chase, Maryland.
- Institute for Diabetes and Cancer, Helmholtz Centre Munich, Neuherberg, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.
- Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
- Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
- Department of Experimental Immunology, Amsterdam Institute of Immunology and Infectious Diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
- Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.
- Laboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.
- Departments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York.
- Department of Animal Physiology, Institute of Biology, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
- Charité - Universitätsmedizin Berlin, corporate member of the Freie Univerität Berlin, Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Berlin, Germany.
- Department of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, Québec, Canada.
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
- Institute of Molecular Physiology (imP), Johannes Gutenberg University Mainz, Mainz, Germany.
- Biomedical Research, Novartis Pharma AG, Basel, Switzerland.
- University of Connecticut Health, Farmington, Connecticut.
- Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California.
- Department of Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
- Department of Chemistry, Institute of Physical Chemistry, University of Basel, Basel, Switzerland; Department of Biosystems Sciences and Engineering, ETH Zurich, Basel, Switzerland.
- Department of Biology, Ashoka University, Sonipat, India.
- Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
- Centre for Translational Pharmacology, School of Molecular Biosciences, University of Glasgow, Glasgow, UK.
Abstract
Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive assessment of the current understanding of aGPCR biology, including a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches, and model systems for their investigation, as well as emerging approaches for their therapeutic targeting. SIGNIFICANCE STATEMENT: Adhesion G protein-coupled receptors are versatile cell-surface proteins that integrate structural, biochemical, and physiological functions, with major roles in health and disease. This review summarizes current knowledge of their molecular features, functions in diverse model systems, and emerging opportunities for therapeutic targeting, providing a comprehensive resource that connects basic biology with translational applications across multiple scientific disciplines.
MeSH
Tissue Adhesions, Gtp-Binding Proteins, Receptors, G-Protein-Coupled, Pharmacology, Therapeutics