Journal Article Review Epublish
PubMed: 41897449 DOI: 10.3390/antiox15030302
Oxidative Stress in Takotsubo Syndrome: Insights into Extracellular Vesicles and Their Potential Clinical Relevance.
Antioxidants (Basel) 15(3)
Authors: Rosa Ciullo, Saveria Femminò, Maria Felice Brizzi, Pasquale Pagliaro, Claudia Penna
Affiliations
- Department of Clinical and Biological Science, University of Torino, Regione Gonzole 10, 10043 Orbassano, Italy.
- Department of Medical Science, University of Torino, Corso Dogliotti 14, 10126 Turin, Italy.
- National Institute for Cardiovascular Research (INRC), 40126 Bologna, Italy.
Abstract
Takotsubo syndrome (TTS) is an acute and reversible form of heart failure characterized by transient left ventricular dysfunction, typically triggered by acute stress stimuli. TTS, also referred to as "stress cardiomyopathy", may paradoxically be triggered not only by negative stressors but also by intense positive emotional experiences. Interestingly, TTS was sharply incremented during and following the COVID-19 pandemic. Despite increased clinical recognition, reliable biomarkers for early diagnosis and prognosis remains limited. Oxidative stress is increasingly recognized as a key mechanism in TTS, acting downstream of sympathetic overactivation, thus contributing to myocardial stunning, endothelial dysfunction, and inflammation. In this context, extracellular vesicles (EVs) have emerged as key mediators of intercellular communication and as potential circulating biomarkers, as they reflect the molecular state of their cells of origin. In this review, we summarize the current diagnostic approaches for TTS, including the InterTAK Diagnostic Score, imaging gold standards, and emerging biomarkers such as circulating miRNAs and EV cargo associated with TTS. Furthermore, we critically examine the mechanistic interplay between oxidative stress and EVs in TTS, highlighting translational perspectives and future directions for integrating EV-based biomarkers into personalized clinical management.
MeSH
Extracellular Vesicles, Heart Failure, Stress, Physiological, Oxidative Stress, Biomarkers, Takotsubo Cardiomyopathy