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Publications

Journal Article Ahead of print

PubMed: 41921910 DOI: 10.1016/j.avsg.2026.03.013

A Core Outcome Set for Intact Abdominal Aortic Aneurysms Under Surveillance.

Ann Vasc Surg

Authors: Sabrina L M Zwetsloot, Lotte Rijken, Igor Koncar, Marina Dias-Neto, Regent Lee, Riikka Tulamo, Christian-Alexander Behrendt, Fabien Lareyre, Noeska N Smit, Stefan P M Smorenburg, Venkat Ayyalasomayajula, Vincent Jongkind, Kak Khee Yeung

Affiliations

  • Department of Surgery, Amsterdam University Medical Centers, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Atherosclerosis & Aortic diseases, Amsterdam, The Netherlands.
  • Department of Surgery, Amsterdam University Medical Centers, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Atherosclerosis & Aortic diseases, Amsterdam, The Netherlands; Amsterdam Public Health, Digital Health, Amsterdam, the Netherlands.
  • Medical Faculty University of Belgrade, Belgrade, Serbia; Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia, Belgrade, Serbia.
  • Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal; RISE-Health, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.
  • Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
  • Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland; Department of Vascular Surgery, University of Helsinki, Helsinki, Finland.
  • Department of Vascular and Endovascular Surgery, Asklepios Clinic Wandsbek, Asklepios Medical School, Hamburg, Germany.
  • Université Côte d'Azur, CNRS, UMR7370, LP2M, Nice, France; Department of Vascular Surgery, Hospital of Antibes Juan-les-Pins, France.
  • Department of Informatics, University of Bergen, Bergen, Norway; MMIV, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
  • Department of Surgery, Amsterdam University Medical Centers, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Atherosclerosis & Aortic diseases, Amsterdam, The Netherlands; Department of Surgery, Amsterdam University Medical Center, Location Vrije Universiteit Amsterdam, Boelelaan 1117, Amsterdam. The Netherlands.
  • Department of Surgery, Amsterdam University Medical Centers, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Atherosclerosis & Aortic diseases, Amsterdam, The Netherlands; Department of Surgery, Amsterdam University Medical Center, Location Vrije Universiteit Amsterdam, Boelelaan 1117, Amsterdam. The Netherlands.

Abstract

OBJECTIVES

Current literature on AAA is characterized by selective outcome reporting, while guideline recommendations are frequently based on studies of poor methodological quality. To improve evidence synthesis, standardization of outcome measures through a core outcome set (COS) is advocated, particularly in artificial intelligence (AI) research. A COS consists of essential outcomes for reporting in clinical research based on patient and expert consensus. This study aimed to create a COS for research on patients with AAA under surveillance. This COS will be innovatively applied in AI research focused on cardiovascular disease progression.

METHODS

First, a longlist of AAA outcomes was identified through a systematic literature search and focus groups with patients, caregivers, and healthcare professionals. A three-round European Delphi survey was subsequently conducted with patients and healthcare professionals. In an expert consensus meeting with key opinion leaders and patients, the COS was finalized.

RESULTS

The 91-outcome AAA longlist was used in the Delphi study, in which 104 patients and 153 healthcare professionals participated. The highest-rated outcomes from the third Delphi round were discussed in the expert consensus meeting, attended by 23 key opinion leaders, two patients and one patient representative from a patient society. Ten core pre- and postoperative outcomes were chosen across six health domains, with AAA rupture, survival, health-related quality of life, clinical success, and graft infection attaining 100% consensus for inclusion in the COS.

CONCLUSION

This COS consists of ten outcomes and should be implemented in clinical and AI research on AAA under surveillance.

MeSH

Quality Of Life, Aortic Aneurysm, Aneurysm, Research, Artificial Intelligence, Vascular Surgical Procedures, Aortic Aneurysm, Abdominal