Journal Article Review Ahead of print 1 citation
PubMed: 41966866 DOI: 10.1016/j.tem.2026.03.009
Understanding hypoparathyroidism as a disease of broad functional deficiency.
Trends Endocrinol Metab
Authors: Maria Luisa Brandi, Jean-Philippe Bertocchio, Istvan Takacs, Ellen K Colman, Ying Kong, Lars Rejnmark, Aliya A Khan
Affiliations
- FIRMO Italian Foundation for the Research on Bone Diseases, Florence, Italy.
- Thyroid-Endocrine Tumors Department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France.
- Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.
- Global Medical Affairs, Alexion, AstraZeneca Rare Disease, Boston, MA, USA.
- Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
- Division of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada.
Abstract
Hypoparathyroidism (HypoPT) is a rare disease defined by undetectable, low, or inappropriately normal parathyroid hormone (PTH) concentrations in the presence of hypocalcemia. Calcium and active vitamin D are often used for the treatment of HypoPT but do not address the underlying lack of physiological PTH activity. In this review, we discuss how the chronic inadequacy of PTH leads to broad functional consequences. This functional deficiency results in a wide spectrum of symptoms, impaired functioning and quality of life, and significant economic and healthcare costs. We consider how kidney complications could develop in patients with HypoPT and highlight recent developments in understanding the heterogeneity of bone health in HypoPT, including certain patient populations.
MeSH
Parathyroid Hormone, Hypoparathyroidism, Kidney, Hormones, Endocrine Glands, Endocrine System Diseases