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Publications

Journal Article Ahead of print

PubMed: 41991444 DOI: 10.1016/j.tig.2026.03.011

The gut microbiome as an effector of metabolic disease gene variants.

Trends Genet

Authors: Rebecca C Simpson, Harry B Cutler, David E James, Stewart W C Masson

Affiliations

  • Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia; Melanoma Institute Australia, Sydney, New South Wales, Australia; Translational Research Collective, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.
  • Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.

Abstract

Here, we discuss emerging studies that have identified overlap in the genetic drivers of the gut microbiome and metabolic disease, and we evaluate the possibility that some genes affecting host metabolic function do so by first manipulating the microbiome.

MeSH

Genes, Genetics, Metabolic Diseases, Gastrointestinal Microbiome