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Publications

Journal Article Ahead of print

PubMed: 42012880 DOI: 10.1097/PAS.0000000000002561

Low-Grade Nasopharyngeal Papillary Adenocarcinoma: Toward a Better Molecular, Epigenetic, and Clinicopathological Understanding With Ontological Perspective.

Am J Surg Pathol

Authors: Eric Lagrue, Nazim Benzerdjeb, Marick Laé, Marie-Delphine Lanic, Daniel Pissaloux, Fabienne Narducci, Hamza Benderradji, Anne Champagnac, Clémentine Decamps, Yvan Nicaise, Emmanuelle Uro-Coste, Valérie Costes-Martineau, Charles Lépine

Affiliations

  • Department of Pathology, CHU Nantes, Nantes University.
  • Department of Pathology, Pathology Institute, Hospices Civils de Lyon, South Lyon Hospital, Pierre-Bénite.
  • Department of Pathology, Henri Becquerel Center.
  • INSERM U1245, Cancer Center Henri Becquerel, Institute of Research and Innovation in Biomedicine (IRIB), University of Normandy, UNIROUEN, Rouen.
  • Department of Biopathology, Leon Berard Center.
  • Team Genetics, Epigenetics and Biology of Sarcomas, Lyon Cancer Research Center, INSERM U1052-CNRS UMR5286, Léon Bérard Center, Claude Bernard Lyon 1 University, Lyon.
  • Molecular Biology and Biochemistry department, CHU Lille.
  • Department of Endocrinology, Diabetology, and Metabolism, CHU Lille, Inserm U1172, Lille Neuroscience and Cognition, University of Lille, Lille.
  • INSERM U1037, Toulouse Cancer Research Centre (CRCT).
  • Department of Pathology, University Hospital of Toulouse, University Cancer InstituteOncopole, Toulouse.
  • Department of Pathology, University Hospital, Montpellier, France.
  • INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302/EMR6001, Nantes.

Abstract

This study reports 6 cases of low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) reviewed by the REFCOR network, integrating clinicopathological, genetic, and epigenetic analyses to refine our understanding of its histogenesis and biological behavior. Our 6 cases were located in the nasopharynx. Histologically, 5 cases had a frank papillary architecture, whereas 1 case showed a mixed papillary and tubular architecture. Papillary and tubular structures were covered by a single layer of epithelium of nonciliated cuboidal or columnar neoplastic cells. Squamous differentiation foci were present in 2 cases. Neither desmoplastic stroma, vascular invasion, nor perineural invasion was seen. All cases expressed TTF1. Neither local recurrence nor metastasis occurred in any of our cases, nor in the literature when only TTF1-positive cases are considered. At the molecular level, in the 3 cases that underwent CGH array and RNA sequencing, we did not find significant molecular anomalies. Our 3 LGNPPAs with DNA methylation analysis were closely grouped on the UMAP with posterior pituitary tumors. Furthermore, comparison of LGNPPA and low-grade non-ITAC sinonasal adenocarcinoma transcriptomes highlighted CNS-related genes as significantly upregulated in LGNPPAs. In conclusion, our transcriptomic and epigenetic data suggest a putative link to a shared progenitor with pituicyte-derived tumors. Our clinicopathological findings are consistent with the literature, highlighting a very indolent behavior.

MeSH

Genes, Nasopharynx, Neoplasms, Adenocarcinoma, Adenocarcinoma, Papillary, Pathology, Surgical