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Publications

Journal Article Practice Guideline Ahead of print

PubMed: 42034552 DOI: 10.1016/j.arbres.2026.04.001

Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): An Official 2025 ALAT Clinical Practice Guideline.

Arch Bronconeumol

Authors: María Laura Alberti, Santiago José Auteri, Jorge Rojas-Serrano, Gustavo Citera, Ivette Buendía-Roldan, Alejandra Babini, Carlos Vinicio Caballero, Antonio Cachafeiro, Juan Ignacio Enghelmayer, Matías Florenzano, Rodrigo García-Salinas, Vicente Girón Atoche, Licia María Henrique da Mota, Ronaldo Adib Kairalla, Agustín Acuña Izcaray, Efraín Sanchez-Angarita, Ricardo Machado Xavier, Mayra Mejía, Karin Mueller Storrer, María Belén Noboa-Sevilla, Lorena Noriega-Aguirre, Emily Rincón-Alvarez, Javier Rosa, Esther Tavera, Carlos Enrique Toro Gutierrez, Verónica Wolff, Philippe Dieudè, Fabián Matías Caro

Affiliations

  • Hospital de Rehabilitación Respiratoria María Ferrer, Buenos Aires City, Argentina.
  • Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
  • Instituto Nacional de Rehabilitación Psicofísica, Buenos Aires City, Argentina.
  • National Institute of Respiratory Diseases-Mexico (INER), Mexico City, Mexico.
  • Hospital Italiano, Córdoba, Argentina.
  • Uribe - Universidad del Norte, Barranquilla, Colombia.
  • Pacífica Salud, Panamá, Panama.
  • Hospital de Clínicas Universidad de Buenos Aires, Buenos Aires City, Argentina.
  • Clínica Universidad de los Andes, Santiago de Chile, Chile.
  • Hospital Italiano La Plata, La Plata, Buenos Aires, Argentina.
  • Hospital Loayza, Lima, Peru.
  • Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil.
  • Instituto do Coraçao, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Centro Médico Docente La Trinidad, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela.
  • Omni Hospital, Guayaquil, Guayas, Ecuador.
  • Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Universidade Federal do Paraná - UFPR, Curitiba, PR, Brazil.
  • Hospital Metropolitano de Quito, Quito, Ecuador.
  • Centro de Diagnóstico y Tratamiento de Enfermedades Respiratorias CEDITER, Ciudad de Panamá, Panama.
  • Fundación Neumológica, Bogotá, Colombia.
  • Hospital Italiano de Buenos Aires, Buenos Aires City, Argentina.
  • Hospital Regional Universitario José María Cabral y Báez, Santiago de los Caballeros, Dominican Republic.
  • Mc Master University, St. Joseph's Hamilton Healthcare, Ontario, Canada.
  • Instituto Nacional del Torax, Santiago de Chile, Chile.
  • Hôpital Bichat - Claude-Bernard-APHP, Paris, FR, France.
  • Hospital de Rehabilitación Respiratoria María Ferrer, Buenos Aires City, Argentina.

Abstract

Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a serious extra-articular manifestation, being the second cause of death in patients with RA. Usual interstitial pneumonia is the most frequent form of ILD with several factors resembling idiopathic pulmonary fibrosis. Early recognition of ILD through screening could change treatment strategies and prognosis in patients with RA. In this sense achieving articular activity remission included in the treat to target strategy becomes one of the most important factors not only to diminish the risk for developing ILD but also disease progression. Disease-modifying antirheumatic drugs (DMARDs) became the cornerstone for treating patients with RA-ILD together with antifibrotics for those with progressive pulmonary fibrosis. Therefore, this guideline aims to support early recognition and evidence -based management of this condition.

MeSH

Idiopathic Pulmonary Fibrosis, Lung, Fibrosis, Arthritis, Disease Progression, Pulmonary Fibrosis, Arthritis, Rheumatoid, Lung Diseases, Lung Diseases, Interstitial