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Publications

Journal Article Ahead of print

PubMed: 42052946 DOI: 10.1093/eurjcn/zvag115

Remote Sophrology in Congenital Heart Disease: The SOPHROCARE Randomized Controlled Trial.

Eur J Cardiovasc Nurs

Authors: Johan Moreau, Caroline Neyraud, Helena Huguet, Mathieu Andrianoely, Huguette Romieu, Françoise Charbonnier, Sophie Guillaumont, Gregoire De La Villeon, Marie Vincenti, Anne Requirand, Annie Auer, Yves Dulac, Aitor Guitarte, Philippe Acar, Fanny Bajolle, Damien Bonnet, Julie Chabaneix, Xavier Iriart, Jean-Benoit Thambo, Laurianne Le Gloan, Quentin Hauet, Alyssia Venna, Anne Cadene, Marie-Christine Picot, Claire Duflos, Pascal Amedro

Affiliations

  • Unit of Pediatric Pulmonology and Cardiology, Department of Pediatrics, M3C Regional Reference Center, Montpellier University Hospital, 3710 Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.
  • PhyMedExp, INSERM 1046, University of Montpellier, 163 r Auguste Broussonnet, 34090 Montpellier, France.
  • Pediatric and Congenital Cardiology Department, M3C National Reference Center, Bordeaux University Hospital, 311 Président Wilson boulevard, 33200 Bordeaux, France.
  • Epidemiology and Clinical Research Department, University Hospital, 3710 Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.
  • IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM 1045, Bordeaux University Foundation, Avenue du Haut Leveque, 33600 Pessac, France.
  • Pediatric Cardiology and Rehabilitation Unit, Saint-Pierre Institute, 371 av Evêché de Maguelone, 34250, Palavas-Les-Flots, France.
  • Pediatric and Congenital Cardiology Department, M3C Regional Reference Center, Toulouse University Hospital, 2 Rue Viguerie, 31059, Toulouse, France.
  • Congenital and Pediatric Cardiology Department, AP-HP, Necker-Enfants Malades University Hospital, M3C National Reference Center, Paris Cité University, 6 Impasse de l'Enfant Jesus, 75015, Paris, France.
  • Pediatric and Congenital Cardiology Department, M3C Regional Reference Center, Nantes University Hospital, 5 allée de l'Île-Gloriette 44093 Nantes Cedex 01, Nantes, France.
  • Heart and Lung Center, Division of Cardiac Surgery, Children's National Hospital, 111 Michigan Ave NW, Washington DC, USA.
  • Department of Clinical Research and Innovation, Montpellier University Hospital, 3710 Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.
  • Clinical Investigation Center, INSERM U1411, Montpellier University Hospital, University of Montpellier, 3710 Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.

Abstract

AIMS

Despite significant medical advances in recent decades, cardiopulmonary fitness decreases faster in youth with congenital heart disease (CHD) than in healthy peers, resulting in impaired health-related quality of life (HRQoL) and increased cardiovascular risk. Apart from cardiac rehabilitation, non-pharmacological preventive interventions have been scarcely evaluated in this population. Sophrology, a mind-body method involving dynamic relaxation in full awareness, breathing exercises, and imagination, has demonstrated benefits for mental health and well-being. This multicenter randomized controlled trial evaluated the impact of a remote sophrology program on cardiopulmonary fitness and HRQoL in youth with CHD.

METHODS AND RESULTS

A total of 200 13-to-25-year-old CHD patients were randomly assigned to either the intervention (i.e., eight remote individual sophrology sessions), or the standard of care. The primary outcome was the change in maximum oxygen uptake (VO2max) measured by cardiopulmonary exercise testing from baseline to 12 months. Secondary outcomes included HRQoL and mental health assessments. No significant VO2max group difference was observed (mean difference -0.11; 95% CI -2.02, 1.79; p=0.91). The HRQoL "Mental Component Summary", "Mental Health" and "Vitality" SF-36 scores increased in the young adult intervention subgroup (18-25 years) by 8.98 (95% CI 2.73; 15.23, p<0.01, effect size 0.84), 14.49 (95% CI 3.17; 25.81, p=0.01, effect size 0.74), and 15.75 (95% CI 3.97; 27.53, p<0.01, effect size 0.78) points, respectively.

CONCLUSION

The remote sophrology program did not improve cardiopulmonary fitness, but significantly enhanced HRQoL in young adults with CHD. Integrating mind-body practices into preventive cardiology programs should be further evaluated. Registration:  Clinicaltrials.gov (NCT03999320).

MeSH

Heart Defects, Congenital, Exercise, Quality Of Life, Heart Diseases, Heart, Mental Health