Journal Article Ahead of print
PubMed: 42148825 DOI: 10.1093/nutrit/nuag065
Effects of Fat-Soluble Vitamins on Gut Microbiome Composition: A Scoping Review.
Nutr Rev
Authors: Joyce Jia Xin Lim, Nevvin Raaj Morgan, Saatheeyavaane Bhuvanendran, Pushpamalar Janarthanan, Ammu K Radhakrishnan
Affiliations
- School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Subang Jaya, Selangor 47500, Malaysia.
- Food as Medicine Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Subang Jaya, Selangor 47500, Malaysia.
Abstract
As the gut microbiome emerges as a key player in human health, numerous studies have reported its close association with various diseases. Consequently, increasing attention has been given to exploring whether fat-soluble vitamins can modulate gut microbiome composition as a potential strategy to maintain microbial balance. This scoping review aimed to investigate whether interventions with fat-soluble vitamins (vitamins A, D, E, and K) could alter gut microbiome composition and, in turn, improve health outcomes. A total of 17 human studies and 47 animal studies were identified across 4 databases. Most studies reported that fat-soluble vitamins effectively altered gut microbiome composition; however, evidence linking these changes to consistent improvements in health outcomes remains limited. Overall, this review maps the potential link between vitamin-driven microbiome modulation and health benefits, while highlighting current research gaps to guide future investigations.
MeSH
Vitamins, Diet, Gastrointestinal Microbiome