Journal Article Review Epublish
PubMed: 42194138 DOI: 10.3390/children13050612
Down Syndrome Births Among Live Births from the CDC Wonder Database.
Children (Basel) 13(5)
Authors: Stephanie L Santoro, Chance Alvarado, Stephen A Hart, Thomas Casto, Clifford L Cua
Affiliations
- Massachusetts General Hospital, Boston, MA 02114, USA.
- Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
- Nationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
- Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
- Biostatistics Resource at Nationwide Children's Hospital, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Abstract
We evaluated the birth rate of Down syndrome (DS) in the CDC birth certificate online database. From 2016 to 2025, live birth incidence could range greatly (depending on the proportion of unknown cases that are counted as DS+) due to relatively high numbers of unknown/not stated status. The annual live birth incidence of DS in live-born infants using CDC birth certificate data from 2016 to 2025 shows a wide range of potential birth rates as calculated here, due to relatively high numbers of unknown/not stated DS status. Although our findings overlap with published data, future studies are needed to further evaluate the current birth rate of DS in the US.
MeSH
Birth Rate, Down Syndrome, Parturition, Incidence, Birth Certificates, Live Birth