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Publications

Journal Article Ahead of print

PubMed: 42219995 DOI: 10.1177/0271678X261454164

EXPRESS: Quantification of 18F-SynVesT-1 binding in healthy aging and head-to-head comparison with 11C-UCB-J.

J Cereb Blood Flow Metab

Authors: Greet Vanderlinden, Charles Carron, Jolien Van Opstal, Marie Cohilis, Wim Vandenberghe, Michel Koole, Koen Van Laere

Affiliations

  • Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Leuven, Belgium. Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium.
  • Laboratory for Parkinson Research, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium. Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Laboratory for Parkinson Research, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium.

Abstract

Synaptic vesicle glycoprotein 2A (SV2A) PET imaging enables the estimation of synaptic density in the brain. The most widely used SV2A tracer, 11C-UCB-J, shows age-related effects in healthy volunteers (HV) and its short radioactive half-life limits clinical applicability. 18F-SynVesT-1 has a longer half-life, but its quantification and dependence on age/sex need further validation. In this study, 40 HV aged 24-85 (21F/19M) underwent 90-minute 18F-SynVesT-1 PET-MR with arterial sampling. Distribution volumes (VT) and distribution volume ratios (DVR) were estimated using 1-tissue (1TC) and 2-tissue (2TC) compartment models, and Logan Graphical Analysis (LGA). 1TC and LGA showed strong agreement with 2TC VT (R²≥0.97). Standardized uptake value ratios (SUVR) were evaluated across different time windows, using the centrum semiovale (CSO) and cerebellar (pseudo)reference regions. SUVRCSO 60-90 min correlated best with DVRCSO. The thalamus and cingulate cortex showed age-related decreases in 18F-SynVesT-1 DVRCSO (~2% per decade). Ten subjects (52±21 years; 5F/5M) also underwent 11C-UCB-J PET for a head-to-head comparison. 18F-SynVesT-1 showed lower cortical VT (-7±9%) but higher DVRCSO (37±4%). This study shows that 18F-SynVesT-1 can be reliably quantified by SUVR in healthy volunteers, and correlates well with 11C-UCB-J. These findings support the broader application of 18F-SynVesT-1. This study was registered on clinicaltrial.gov (NCT05384353).

MeSH

Aging, Healthy Volunteers, Tissues, Healthy Aging