Journal Article Epublish
PubMed: 42238257 DOI: 10.1210/jendso/bvag052
Targeted proteomics reveal association between maternal biomarkers and child body weight in the first year of life.
J Endocr Soc 10(6):bvag052
Authors: Noura Kabbani, Thomas Ebert, Holger Stepan, Massimiliano Lia, Matthias Blüher, Ronny Baber, Mandy Vogel, Ronald Biemann, Wieland Kiess, Anke Tönjes, Susanne Schrey-Petersen
Affiliations
- Clinic and Polyclinic for Gynaecology, University of Leipzig Medical Center, Leipzig 04103, Germany.
- Leipzig Reproductive Health Research Center, Leipzig University, Leipzig 04103, Germany.
- Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig 04103, Germany.
- Department of Obstetrics, University of Leipzig Medical Center, Leipzig 04103, Germany.
- Helmholtz Institute for Metabolic, Obesity and Vascular Research of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig 04103, Germany.
- Leipzig Medical Biobank, University of Leipzig Medical Center, Leipzig 04103, Germany.
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig 04103, Germany.
- LIFE Child, Hospital for Children and Adolescents, Department of Pediatrics, University of Leipzig Medical Center, Leipzig 04103, Germany.
- German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig 04103, Germany.
Abstract
CONTEXT
The intrauterine environment strongly influences children's health and development. Distinct cardiovascular biomarkers have been linked to birth weight and later weight gain, with correlations observed in maternal and umbilical cord serum.
OBJECTIVE
To describe (1) maternal cardiovascular biomarker patterns during the second and third trimesters and (2) potential associations between these biomarkers and offspring weight at birth and at 1 year of age.
DESIGN
Within the LIFE Child Study, serum samples from 86 healthy mothers at 24 and 36 gestational weeks and cord blood at birth were analyzed using the Olink® Target 96 Cardiovascular III panel. Statistical analyses (Wilcoxon test, Spearman correlation, multivariate regression) were performed in R.
SETTING
Community-based cohort, Leipzig, Germany.
PATIENTS OR OTHER PARTICIPANTS
Eighty-six mother-child pairs from the LIFE Child cohort. Mothers had no pregnancy complications, and all newborns had birth weights between 2500 and 4500 g.
MAIN OUTCOME MEASURE
Offspring body weight at 1 year of age.
RESULTS
Of 92 maternal serum biomarkers, 88 were detectable. Seventy biomarkers increased significantly from 24 to 36 weeks (P < .004). Several biomarkers measured at the 36th gestational week correlated with birth weight and 1-year weight. After adjustment for maternal age, body mass index, and offspring sex, no associations remained with birth weight. However, maternal paraoxonase 3 (PON3) [P = .037, 95% confidence interval (CI): -0.52, -0.02] and integrin subunit β 2 (ITGB2) (P = .038, 95% CI: 0.04, 1.12) were significantly associated with child weight at 1 year.
CONCLUSION
In our cohort, maternal PON3 and ITGB2 were independently associated with early postnatal growth, potentially implicating these biomarkers in fetal programming.
MeSH
Mothers, Serum, Parturition, Biomarkers, Birth Weight, Proteomics, Body Weight, Child