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Publications

Journal Article Ahead of print

PubMed: 42246605 DOI: 10.1093/mmy/myag059

Seasonal variations in mold identification in medical microbiology laboratories using MSI-2 application, France (2020-2024).

Med Mycol

Authors: Arnaud Jabet, Anne-Cécile Normand, Laurence Delhaes, Pierre-Yves Boelle, Pamela Chauvin, Maria-Alexandra Stoica, Laurence Lachaud, Frédéric Dalle, Lilia Hasseine, Juliette Guitard, Yaye Senghor, Christine Bonnal, Marie Lavollay, Caroline Mahinc, Christine Schuttler, Anne-Pauline Bellanger, Noémie Coron, Françoise Botterel, Cécile Garnaud, Eric Dannaoui, Lucie Limousin, Antoine Huguenin, Edith Mazars, Aymeric Coutard, Jean-Pierre Gangneux, Guillaume Laurent, Damien Dupont, Solene Le Gal, Sébastien Larréché, Chrystelle Darles, Boualem Sendid, Sophie Brun, Fabienne Artur, Taieb Chouaki, Patrice Le Pape, Nicolas Bruffaerts, Pierre Becker, Arnaud Fekkar, Renaud Piarroux

Affiliations

  • Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Mycology-Parasitology Department, APHP, La Pitié-Salpêtrière Hospital, Paris, France.
  • Mycology-Parasitology Department, APHP, La Pitié-Salpêtrière Hospital, Paris, France.
  • Mycology-Parasitology Department, University Hospital of Bordeaux, Bordeaux, France.
  • Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Réseau Sentinelles, Paris, France.
  • Mycology-Parasitology Department, University Hospital of Toulouse, Toulouse, France.
  • Mycology-Parasitology Department, University Hospital of Rouen, Rouen, France.
  • Mycology-Parasitology Department, University Hospital of Montpellier, Montpellier, France.
  • Université Bourgogne Europe, CHU Dijon Bourgogne, Laboratoire de Parasitologie Mycologie, Institut Agro, INRAE, UMR PAM, 21000 Dijon, France.
  • Mycology-Parasitology Department, University Hospital of Nice, Nice, France.
  • Sorbonne Université, INSERM, Centre de rechercher Saint-Antoine, Mycology-Parasitology Department, APHP, Hôpital Saint-Antoine, Paris.
  • Microbiology department, Hôpital Saint-Joseph et Marie-Lannelongue, Paris, France.
  • Mycology-Parasitology Department, APHP, Hôpital Bichat, Paris, France.
  • Microbiology Department, Institut Médico-chirurgical Montsouris, Paris, France.
  • Mycology-Parasitology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
  • Biogroup Paris-Ouest, Levallois-Perret, France.
  • Mycology-Parasitology Department, University Hospital of Besançon, France.
  • Biogroup Côte d'Azur, Mouans-Sartoux, France.
  • Mycology-Parasitology Department, APHP, Hôpital Henri Mondor, Créteil, France.
  • Mycology-Parasitology Department, University Hospital of Grenoble, Grenoble, France.
  • Mycology-Parasitology Department, APHP, Hôpital Necker, Paris, France.
  • Microbiology Department, Hôpital Foch, Suresnes, France.
  • Mycology-Parasitology Department, University Hospital of Reims, France.
  • Microbiology Department, Centre Hospitalier de Valenciennes, Valenciennes, France.
  • Microbiology Department, Centre Hospitalier René Dubos, Pontoise, France.
  • Mycology-Parasitology Department, University Hospital of Rennes, Rennes, France.
  • Mycology-Parasitology Department, University Hospital of Tours, Tours, France.
  • Mycology-Parasitology Department, University Hospital of Lyon, Lyon, France.
  • Mycology-Parasitology Department, University Hospital of Brest, Brest, France.
  • Microbiology Department, Hôpital national d'instruction des armées Bégin, Saint-Mandé, France.
  • Microbiology department, Hôpital d'instruction des Armées, Toulon, France.
  • Mycology-Parasitology Department, University Hospital of Lille, France.
  • Mycology-Parasitology Department, APHP, Hôpital Avicenne, Bobigny, France.
  • Laboratoire Biocéane, Le Havre, France.
  • Mycology-Parasitology Department, University Hospital of Amiens, Amiens, France.
  • Mycology-Parasitology Department, University Hospital of Nantes, Nantes, France.
  • BCCM/IHEM, Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium.
  • Sorbonne Université, INSERM, CNRS, Centre d'immunologie et des Maladies infectieuses (Cimi-Paris), APHP, Hôpital Pitié-Salpêtrière, Service de Parasitologie-Mycologie, Paris, France.

Abstract

Molds are ubiquitous environmental microorganisms with major implications for human health, ranging from allergic reactions to invasive infections. Although the environmental seasonality of several fungal spores has long been recognized, its reflection in clinical isolates remains poorly explored. A total of 218,682 fungal spectra generated by 97 medical microbiology laboratories across France between 2020 and 2024 were analyzed, based on identifications performed using the MSI-2 MALDI-TOF MS web platform. Seasonal patterns were assessed through additive decomposition, autocorrelation, and formal statistical testing. Distinct seasonal variation patterns were identified across taxa. Significant seasonality was detected for multiple taxa, including Alternaria, Cladosporium, Aspergillus sections Nigri and Flavi, Talaromyces, several taxa of Basidiomycota, and Rhizopus arrhizus. Positive or negative correlations between fungal identification counts and national mean temperature values were observed depending on the taxon. This study highlights the importance of considering seasonality in understanding the epidemiology of fungal diseases and demonstrates the value of multicenter MALDI-TOF MS data as a tool for epidemiological surveillance.

MeSH

Laboratories, Microbiology