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Publications

Journal Article Review Ahead of print

PubMed: 42247056 DOI: 10.1007/s40487-026-00447-6

Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review.

Oncol Ther

Authors: Marvin C Masalunga, Patrick J Bradley, Carla van Herpen, Toshitaka Nagao, Göran Stenman, Vincent Vander Poorten, Henrik Hellquist, Silvana Di Palma, Martina Bradová, Ilmo Leivo, Alfio Ferlito, Alena Skálová

Affiliations

  • Bioptical Laboratory, Pilsen, Czech Republic.
  • School of Medicine, Southwestern University PHINMA, Cebu City, Philippines.
  • Department of Otolaryngology-Head and Neck Surgery, Nottingham University Hospitals, Queens Centre Campus, Nottingham, UK.
  • Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
  • Department of Laboratory Medicine/Pathology, Sahlgrenska University Hospital, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
  • Department of Oncology, section Head and Neck Oncology, Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
  • Multidisciplinary Salivary Gland Society, Geneva, Switzerland.
  • Faculty of Medicine and Biomedical Sciences (FMCB), Algarve Biomedical Center Research Institute (ABC-RI), University of Algarve, Faro, Portugal.
  • Department of Cellular Pathology, Northern Lincolnshire and Goole NHS Foundation Trust, Lincoln, UK.
  • Department of Pathology, Royal Surrey County Hospital, Guilford, Surrey, UK.
  • Department of Pathology, Medical Faculty Hospital, Charles University, Faculty of Medicine in Pilsen, Dr. E. Benese 13, 305 99, Pilsen, Czech Republic.
  • Department of Pathology, Turku University Central Hospital, Institute of Biomedicine, University of Turku, Turku, Finland.
  • International Head and Neck Scientific Group, Padua, Italy.
  • Bioptical Laboratory, Pilsen, Czech Republic. Department of Pathology, Medical Faculty Hospital, Charles University, Faculty of Medicine in Pilsen, Dr. E. Benese 13, 305 99, Pilsen, Czech Republic.

Abstract

Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor prognosis, researchers have focused on identifying factors and driver genomic alterations that may account for its behavior, ultimately yielding potential therapeutic targets. This review summarizes the growing body of knowledge on SDC since the publication of the latest WHO Classification of Tumors of the Head and Neck. Updates on emerging subtypes, immunohistochemical profiles, molecular alterations, and potential therapeutic targets are succinctly presented. Findings from studies on tumor immune microenvironment (TIME), which may have implications for the treatment and prognosis of SDC, are also discussed in this narrative review.

MeSH

Neoplasms, Salivary Ducts, Therapeutics, Prognosis