Journal Article Epublish
PubMed: 42255668 DOI: 10.1002/fsn3.71914
Lanzhou Lily (Lilium davidii var. unicolor) Extract Alleviates Chronic Stress-Induced Mood Disturbances by Suppressing Neuroinflammation and Modulating the Gut-Brain Axis in Mice.
Food Sci Nutr 14(6):e71914
Authors: Ziyi An, Yuanyuan Xin, Yongfei Wang, Ting Wang, Junqiang Niu, Xiaogang Hu, Xiangkai Li, Weilin Jin
Affiliations
- The First Clinical Medical College of Lanzhou University Lanzhou P. R. China. Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University The First Clinical Medical College of Lanzhou University Lanzhou P. R. China.
- Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University The First Clinical Medical College of Lanzhou University Lanzhou P. R. China.
- Traditional Chinese Medicine Department The First Hospital of Lanzhou University Lanzhou P. R. China.
- Pingliang City Traditional Chinese Medicine Hospital Pingliang P. R. China.
- Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences Lanzhou University Lanzhou P. R. China.
Abstract
Chronic stress is a major contributor to mood disturbances through dysregulation of the gut-brain axis and neuroinflammatory responses. Lilium davidii var. unicolor (Lanzhou lily), a traditional medicinal and edible plant, contains bioactive compounds with anti-inflammatory potential. This study investigated the effects of Lanzhou lily extract (LLE) on chronic restraint stress (CRS)-induced behavioral and physiological changes in mice. LLE improved CRS-induced anxiety- and depression-like behaviors, reduced microglial activation in the hippocampus, and suppressed TLR4/MyD88/NF-κB signaling and downstream cytokine release (TNF-α, IL-6, IL-1β). LLE also restored intestinal barrier integrity, decreased serum LPS levels, and modulated gut microbiota composition by enriching Ligilactobacillus murinus and Muribaculum intestinale while reducing Prevotella abundance. Correlation analysis linked microbial restoration with barrier protection and reduced neuroinflammation. UHPLC-Q-Exactive Orbitrap-MS/MS analysis tentatively identified multiple constituents of LLE, including dioscin, matrine, timosaponin AIII, and catechin. Previous studies have suggested that some of these compounds may possess neuroprotective or antidepressant-related activities. These findings suggest that Lanzhou lily extract may modulate the gut-brain axis and exert antidepressant-like effects in a preclinical stress model, warranting further investigation in clinical studies.
MeSH
Depression, Antidepressive Agents, Stress, Physiological, Brain, Catechin, Gastrointestinal Microbiome