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Publications

Journal Article Ahead of print

PubMed: 42309251 DOI: 10.1016/j.envpol.2026.128595

Short-term effects of PM 10 sources and oxidative potential on child lung function.

Environ Pollut

Authors: Cécile Tassel, Gaëlle Uzu, Vy Dinh Ngoc Thuy, Jean-Luc Jaffrezo, Anne Boudier, Anouk Marsal, Catherine Coulaud, Céline Voiron, Joane Quentin, Olivier Favez, Stephane Sauvage, Stephane Socquet, Rémy Slama, Rhabira Elazzouzi, Sarah Lyon-Caen, Sophie Darfeuil, Zoltán Hantos, Claire Philippat, Sam Bayat, Valérie Siroux

Affiliations

  • Université Grenoble Alpes (UGA), CNRS, IRD, Grenoble-INP, INRAE, IGE (Institute of Environmental Geosciences), 38402, Grenoble, France; University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France.
  • Université Grenoble Alpes (UGA), CNRS, IRD, Grenoble-INP, INRAE, IGE (Institute of Environmental Geosciences), 38402, Grenoble, France.
  • University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France.
  • University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France; Department of Pulmonology and Physiology, CHU Grenoble Alpes, Grenoble, France.
  • Laboratoire Central de Surveillance de la Qualité de l'Air (LCSQA), 60550 Verneuil-en-Halatte, France; Institut National de l'Environnement Industriel et des Risques (Ineris), Verneuil-en-Halatte, France.
  • ATMO Auvergne-Rhône-Alpes, 69500 Bron, France.
  • Department of Technical Informatics, University of Szeged, Szeged, Hungary.
  • Department of Pulmonology and Physiology, CHU Grenoble Alpes, Grenoble, France; Université Grenoble Alpes, Inserm UA07 STOBE Laboratory, Grenoble, France.

Abstract

Exposure to particulate matter (PM 10) poses a significant threat to human health. We investigated the effects of short-term exposures to PM 10 sources and oxidative potential (OP), an indicator of PM related to its toxicity, on lung function in early childhood. The study is based on 435 children from the SEPAGES cohort in Grenoble, with lung function measured at 6-8 weeks (N 2 multiple breath washout and tidal breathing flow-volume loop) and 3 years (oscillometry, including resistance and reactance). PM 10 chemical composition and OP (ascorbic acid - AA and dithiothreitol - DTT assays) were measured on filters collected at an urban background station. PM 10 concentrations were attributed to 10 different sources using a source apportionment method. Associations of short-term exposure (1-, 3-, 7- and 14-day) to each source and OP with lung function were estimated by regression models. Increased acute exposure to PM 10 from traffic was associated with parameters indicating impaired lung function at 6-8 weeks and 3 years. Increased exposure to PM 10 from biomass burning and primary biogenic sources was associated with lower intra-breath reactance at 3 years. Total PM 10 mass and other sources showed no association, or were associated with higher lung function. Increased OP AA was consistently associated to lower child lung function. The greatest magnitude was found between 2-week exposure to mass-normalised OP AA and reduced 7-Hz-reactance at 3 years (β=-0.52 hPa×s/L 95%CI: -0.88, -0.15 per 0.07 nmol/min/μg increase). This study suggests that short-term exposure to PM 10 from primary biogenic and local anthropogenic sources, mainly traffic and biomass burning, and to OP may have detrimental effects on early life lung function.

MeSH

Lung, Respiratory System, Air Pollution, Cohort Studies, Biomass, Environmental Pollution, Particulate Matter, Child