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Publications

Journal Article Ppublish

PubMed: 42339517 DOI: 10.1080/25310429.2026.2653434

Occupational category, job type, and sarcoidosis: Findings from a French multicenter study.

Pulmonology 32(1):2653434

Authors: Raphael Lhote, Fleur Cohen Aubart, Hilario Nunes, David Launay, Raphael Borie, Karim Sacré, Nicolas Schleinitz, Antoine Néel, Mohamed Hamidou, Julien Haroche, Matthieu Mahevas, Herve Devilliers, Philippe Bonniaud, François Lhote, Lucile Sesé, Bruno Crestani, Dominique Valeyre, Zahir Amoura, Isabella Annesi-Maesano

Affiliations

  • Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Epidémiologie des maladies Allergiques et Respiratoires (EPAR), Faculté de Médecine Saint-Antoine, Paris, France.
  • Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Centre National de Référence Histiocytoses, Paris, France.
  • Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Service de Pneumologie, Bobigny, France.
  • Université de Lille, CHU de Lille, Inserm, Service de Médecine Interne, Centre de Référence des Maladies Auto-Immunes Systémiques Rares du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), Lille, France.
  • Université Paris Cité, Inserm,Centre de Recherche de l'Inflammation, Paris, France.
  • Service de Pneumologie, Allergologie et Transplantation, AP-HP, Hôpital Bichat, Paris, France.
  • Université Paris-Cité, Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Service de Médecine Interne, Paris, France.
  • Université Aix Marseille, Assistance Publique Hôpitaux de Marseille, Hôpital de la Timone, Service de Médecine Interne, Marseille, France.
  • Université de Nantes, Centre Hospitalier Universitaire, Service de Médecine Interne, Nantes, France.
  • Assistance Publique Hôpitaux de Paris, Hôpital Mondor, Service de Médecine Interne, Créteil, France.
  • Université de Bourgogne, Centre Hospitalier Universitaire, Service de Médecine Interne 2, Dijon, France.
  • Université Bourgogne Europe, CHU Dijon Bourgogne, Centre de Référence Constitutif des Maladies Pulmonaires Rares de l'Adulte, Inserm UMR1231 CTM, Dijon, France.
  • Service de Médecine Interne, Hôpital Delafontaine, St-Denis, France.
  • Department of Pulmonology, Université Sorbonne Paris-Nord, Groupe Hospitalier Paris Saint Joseph, Paris, France.
  • University Hospital Institute (IHU): Immune4Cure, University of Montpellier and INSERM, Montpellier, France.
  • Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France.

Abstract

OBJECTIVES

Evidence supporting an occupational hypothesis for sarcoidosis remains limited. The hypothesis of the present study was that some occupational exposures might be more prevalent among sarcoidosis patients than in the French population.

METHODS

A cross-sectional observational study design was used to collect occupational data from patients enrolled in the Epidemiology ofSarcoidosis (EpiSarc) cohort study with documented sarcoidosis. The data were initiallyclassified according to the occupational classification of the French National Institute ofStatistics and Economic Studies and then compared to employment data fromthe French population for the reference year 2016.

RESULTS

Among the 1,512 sarcoidosis patients included, occupational data were avail- able for 1,177 patients (78%). Of these, 1,086 (92%) were employed at time of sarcoidosis diagnosis. Notably, manual workers were significantly overrepresented compared to the general French population (40% versus 20%, p < 0.0001). Among the 471 manual workers, the distribution of occupations was as follows: construction workers (n = 165, 35%), domestic helpers and cleaners (n = 109, 23%), transportation and handling workers (n = 82, 17.5%), manufacturing labourers and industrial operators (n = 67, 14%), textile indus- try workers (n = 25, 5.5%), and other occupations (n = 23, 5%). The frequency of patients with manual working occupations varied depending on the organ involvement, being the highest in patients with lung involvement.

CONCLUSION

We found that manual workers occupations with exposure to various environmental hazards that may trigger inflammation promoting an abnormal granulomatous immune response, including dust, were associated with sarcoidosis.

MeSH

Dust, Epidemiology, Sarcoidosis, Phenotype, Occupational Exposure, Occupations, Workplace