Journal Article Ppublish
PubMed: 42360287 DOI: 10.1002/alz.71629
Cognitive decline in Dutch-type hereditary and sporadic cerebral amyloid angiopathy: a 5-year follow-up study.
Alzheimers Dement 22(7):e71629
Authors: Rosemarie van Dort, Vera C J van Stek-Smits, Sanne E Schriemer, Reinier G J van der Zwet, Manon R Schipper, Sabine Voigt, Ellen P Hart, Vandhana Easwaran, Hamid R Sohrabi, Kevin Taddei, Samantha L Gardener, Ralph N Martins, Steven M Greenberg, Matthias J P van Osch, Marianne A A van Walderveen, Marieke J H Wermer, Ellis S van Etten
Affiliations
- Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
- Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
- Directorate of Research and Valorisation, Leiden University Medical Center, Leiden, The Netherlands.
- School of Psychology, College of Health and Education, Murdoch University, Perth, Western Australia, Australia. Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia. Alzheimer's Research Australia, Perth, Western Australia, Australia.
- School of Psychology, College of Health and Education, Murdoch University, Perth, Western Australia, Australia.
- Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.
- Alzheimer's Research Australia, Perth, Western Australia, Australia.
- School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
- The University of Western Australia Medical School, Nedlands, Western Australia, Australia.
- Massachusetts General Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
- Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands.
Abstract
INTRODUCTION
Cerebral amyloid angiopathy (CAA) is associated with cognitive impairment, but its longitudinal course of cognitive decline remains unclear. We investigated domain-specific cognitive trajectories in Dutch-type hereditary (D-CAA) and sporadic CAA (sCAA) to compare patterns and rates of decline.
METHODS
We included 181 participants - 93 D-CAA mutation carriers (59 without, 34 with prior intracerebral hemorrhage [ICH]) and 88 with sCAA (57 without, 31 with ICH) - who underwent annual neuropsychological assessment. Longitudinal change in global cognition, memory, processing speed, and executive function was analyzed using linear mixed models.
RESULTS
Over 5 years, cognitive decline was subtle but measurable. Memory and processing speed declined in D-CAA with prior ICH, whereas D-CAA without ICH and sCAA remained relatively stable. Global cognition showed a modest but significant decline, while executive function remained stable.
DISCUSSION
CAA-related cognitive decline appears domain- and stage-dependent, suggesting progressive small-vessel injury rather than acute hemorrhage may drive deterioration.
MeSH
Dementia, Hemorrhage, Follow-Up Studies, Alzheimer Disease, Executive Function, Cognitive Dysfunction, Cognition Disorders, Amyloid, Cerebral Amyloid Angiopathy, Cognition