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Publications

Journal Article Epublish 1 citation

PubMed: 42395078 DOI: 10.1016/j.ajpc.2026.101494

Preconception cardiometabolic markers and odds of developing adverse pregnancy outcomes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Am J Prev Cardiol 28:101494

Authors: Maria A Pabon, Danielle N Tapp, Madison Pico, Catherine J Vladutiu, Christian Schmidt, Emily DeFranco, Shathiyah Kulandavelu, Tali Elfassy, Margo B Minissian, Natalie A Bello, C Noel Bairey Merz, Nour Makarem, Michelle L Meyer, Krista M Perreira, Yanping Teng, Martha Daviglus, Michelle A Kominiarek, Carlos J Rodríguez, Barry E Hurwitz, Gregory A Talavera, Susan Cheng, Odayme Quesada

Affiliations

  • Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Women's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, OH, USA.
  • The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, OH, USA.
  • Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.
  • Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, KY, USA.
  • Department of Pediatrics, Interdisciplinary Stem Cell Institute, Miller School of Medicine, Miami, FL, USA.
  • Department of Medicine, Miller School of Medicine, Miami, FL, USA.
  • Geri and Richard Brawerman Nursing Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Barbra Streisand Women's Heart Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Center, NY, NY, USA.
  • Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Department of Emergency Medince, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Albert Einstein College of Medicine, Bronx, NY, USA.
  • South Bay Latino Research Center, Department of Psychology, San Diego State University, San Diego, CA, USA.
  • Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.

Abstract

BACKGROUND

Adverse pregnancy outcomes (APO) are associated with increased cardiovascular disease (CVD) risk. However, studies evaluating preconception cardiometabolic risk factors and the development of APO are lacking in high-risk, understudied groups including the Hispanic/Latina population.

METHODS

We examined the odds of APO associated with preconception cardiometabolic markers in the prospective cohort of Hispanic Community Health Study/Study of Latinos (HCHS/SOL). APO was defined as self-reported hypertensive disorders of pregnancy (HDP) or gestational diabetes (GDM). Metabolic syndrome was defined per NCEP-ATP III criteria. Women reporting at least 1 pregnancy between baseline (2008-2011) and visit 2 (2014-2017) were included. Multivariate logistic regressions were used to determine the odds of APO.

RESULTS

Among 529 participants, 111 (21 %) reported an APO. In adjusted models, higher preconception systolic blood pressure (SBP), body mass index, waist circumference, HbA1c, and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) were associated with increased odds of APO. A dose-response relationship in metabolic syndrome components, with two and three or more components significantly increasing the odds of developing an APO (adjusted OR 2.50 (1.07, 5.84) and 3.39 (1.37, 8.42)).

CONCLUSION

High-risk preconception cardiometabolic abnormalities increase the odds of developing an APO in Hispanic/Latina women, with a dose-response relationship by the number of metabolic syndrome components. Early identification and intervention are crucial to reduce APOs and their long-term cardiovascular consequences in this population.

MeSH

Pregnancy, Pregnancy Outcome, Public Health, Metabolic Syndrome