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Publications

Journal Article Review Epublish

PubMed: 42397484 DOI: 10.1007/s12016-026-09178-y

Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.

Clin Rev Allergy Immunol 69(1)

Authors: Marc A Riedl, Danny M Cohn, Markus Magerl, Henriette Farkas, Emel Aygören-Pürsün, Aleena Banerji, Jonathan A Bernstein, Alvin H Schmaier, Evangelia Pardali, Anne Lesage, Peng Lu, David E Newby

Affiliations

  • Division of Allergy and Immunology, University of California, La Jolla, San Diego, CA, USA.
  • Amsterdam UMC, Department of Vascular Medicine, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
  • Institute of Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universitätsmedizin Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
  • Department for Children and Adolescents, Goethe University Frankfurt, Frankfurt, Germany.
  • Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA.
  • Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
  • Pharvaris BV, Leiden, The Netherlands.
  • GrayMatters Consulting, Schilde, Belgium.
  • Pharvaris Inc, Lexington, MA, USA.
  • British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, UK.

Abstract

Bradykinin is a nonapeptide of the kinin family with vasoactive and proinflammatory activities. While generation of kinins is mainly driven by activation of the contact system and plasma or tissue kallikreins, additional independent cascades contribute to their formation. Kinins mediate their effects through the constitutively expressed bradykinin B2 receptor and the inducible bradykinin B1 receptor. Bradykinin is the most studied kinin peptide mainly due to its potential role in the vascular system and exerts its effects mainly via the bradykinin B2 receptor. Kinins have been implicated in the pathogenesis of multiple types of angioedema as well as of various conditions, such as allergic mast cell-mediated skin diseases, cardiovascular and respiratory pathologies. This review summarizes our current knowledge of the biology, regulation, and functions of kinins and their receptors as well the emerging evidence on the various mechanisms involved in bradykinin formation and their relevance in disease pathogenesis. The review focuses on the clinical evidence on the roles of bradykinin and of the bradykinin B2 receptor in various conditions, and the potential to develop novel strategies targeting the bradykinin B2 receptor for management of bradykinin-mediated diseases.

MeSH

Hypersensitivity, Kinins, Receptor, Bradykinin B2, Vascular Diseases, Immune System Diseases, Bradykinin, Therapeutics, Receptor, Bradykinin B1