Journal Article Review Ahead of print
PubMed: 42400051 DOI: 10.1002/1873-3468.70402
Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression.
FEBS Lett
Authors: Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K Karamanos
Affiliations
- Biochemistry, Biochemical Analysis and Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504, Greece.
Abstract
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three-dimensional cancer models more accurately reflects in vivo conditions compared to conventional two-dimensional systems. Matrix engineering through bioscaffolds supports physiologically relevant tumor modeling, while matrix-based platforms offer valuable tools for preclinical research and therapeutic development.
MeSH
Neoplasms, Extracellular Matrix