Journal Article Review Ppublish
PubMed: 42429229 DOI: 10.1155/bmri/1172509
Immunometabolic Reprogramming of Fibroblastic Reticular Cells in the Tumor Immune Microenvironment.
Biomed Res Int 2026(1):e1172509
Authors: Tian Tian, Huimin Liu, Peiyan Liu, Shumin Ye, Yudi Wu, Jun Zhou
Affiliations
- Department of Pulmonary and Critical Care Medicine, Changzhou Medical Center, Nanjing Medical University, Changzhou City, China, njmu.edu.cn.
- Department of Pulmonary and Critical Care Medicine, Changzhou Medical Center, Nanjing Medical University, Changzhou City, China, njmu.edu.cn. Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Changzhou, Changzhou City, China.
Abstract
Fibroblastic reticular cells (FRCs), as core stromal cells in secondary lymphoid tissues and the tumor immune microenvironment (TIME), undergo significant immunometabolic reprogramming, which regulates antitumor immune responses. This structured narrative review summarizes the immunometabolic reprogramming of FRCs across various cancers, emphasizing glucose metabolism, lipid remodeling, and amino acid metabolism in lung cancer, breast cancer, gastric cancer, lymphoma, head and neck tumors, and melanoma. Under hypoxia, nutrient stress, and inflammatory stimulation, FRCs enhance glycolysis, alter fatty acid synthesis/oxidation, and disrupt amino acid metabolism, leading to immunosuppressive metabolite secretion, cytokine profile changes, and the formation of immune niches. Understanding these cancer-specific molecular mechanisms can inform targeted immunometabolic therapies.
MeSH
Cells, Breast Neoplasms, Amino Acids, Neoplasms, Stomach Neoplasms