System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article English Abstract Review Ppublish

PubMed: 42439143

[Current methods of systematic serological testing for infections in pregnant women in France].

Rev Prat 76(6):608-612

Authors: Stanley Soussan, Violaine Peyronnet, Christelle Vauloup-Fellous, Olivier Picone

Affiliations

  • Service de gynécologie-obstétrique, hôpital Louis-Mourier, AP-HP, Colombes, France.
  • Université Paris Cité, Paris, France.
  • Service de virologie, WHO Rubella National Reference Laboratory, laboratoire de biologie médicale de référence Virus et périnatalité, hôpital Paul-Brousse, AP-HP, université Paris-Saclay, Villejuif, France.
  • Université Paris-Saclay, Inserm U1184, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses, France.
  • Groupe de recherche sur les infections pendant la grossesse (GRIG).
  • IAME, Inserm et FHU PREMA Paris, France.

Abstract

Serological testing during pregnancy is an integral part of obstetric monitoring. This screening is essentially based on the detection and dosage of specific antibodies (IgM and IgG) of a virus, bacteria or parasite. Currently in France, 4 serologies are mandatory (toxoplasmosis, rubella, syphilis and hepatitis B) but others are recommended and systematically offered (HIV, HCV, CMV). Determination of immune status should ideally be done in the pre-conception period or as soon as possible after the diagnosis of pregnancy. In the absence of immunity (IgM-, IgG-), hygienic and dietary measures are recommended, and the monitoring methods vary with the pathogen concerned. If seroconversion is suspected (IgM+, IgG+), the patient must be referred to a specialized fetal medicine unit to discuss the need for additional testing and to begin treatment if necessary. If there is any doubt about the interpretation of the serology result, it is essential to refer the patient to a prenatal center or to seek advice from a national reference laboratory.

MeSH

Pregnant Women, Research Design, Pregnancy, Syphilis, Rubella, Toxoplasmosis, Infections