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Publications

Journal Article Ahead of print

PubMed: 42455464 DOI: 10.1007/s40292-026-00808-2

Orthostatic Hypotension in Hypertensive Patients Hospitalized in Italian Internal Medicine Departments: FADOI-HYP-OP Study.

High Blood Press Cardiovasc Prev

Authors: Claudio Ferri, Alberto Mazza, Dario Manfellotto, Francesco Dentali, Alberto Moggi Pignone, Maria D'Avino, Roberta Buso, Antonella Valerio, Maria Lorenza Muiesan, Giovanbattista Desideri, Martino Pengo, Grzegorz Bilo, Gianfranco Parati, Andrea Fontanella

Affiliations

  • University of L'Aquila-MeSVA Department and Internal Medicine and Nephrology, Hypertension and Cardiovascular Prevention Unit, San Salvatore Hospital, L'Aquila, Italy.
  • Internal Medicine Department, Rovigo General Hospital, Rovigo, Italy. Internal Medicine Department, San Bortolo General Hospital and Hypertension Center Certified by the Italian Society of Hypertension (SIIA), Vicenza, Italy.
  • Department of Emergency and Internal Medicine,, Isola Tiberina Hospital, Gemelli-Isola, Rome, Italy, Rome, Italy.
  • Department of Medicine, ASST-Settelaghi, Varese, Italy.
  • Internal Medicine 4 Department, Careggi University Hospital, Florence, Italy.
  • Internal Medicine Department, Cardarelli Hospital, Naples, Italy.
  • Internal Medicine Department, "Cà Foncello" Hospital, Treviso, Italy.
  • Research Department, FADOI Foundation, MIND-Viale del Decumano, 32, 20157, Milan, Italy.
  • Internal Medicine Department, University of Brescia and ASST Spedali Civili, Brescia, Italy.
  • Internal Medicine Department, "SS. Filippo e Nicola" Hospital, Avezzano, L'Aquila, Italy.
  • Department of Cardiology, IRCCS, Istituto Auxologico Italiano, Milan, Italy.
  • Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
  • Internal Medicine Department, Fatebenefratelli Hospital, Naples, Italy.

Abstract

INTRODUCTION

Orthostatic hypotension (OH) is defined as a decline in systolic blood pressure of at least 20 mmHg or a reduction in diastolic blood pressure of at least 10 mmHg, within the first 3 min of standing.

AIM

To evaluate the prevalence of OH and to identify the characteristics of patients with OH in hypertensive patients hospitalized in medical inpatient departments.

METHODS

A multicenter, observational, prospective study (FADOI-HYP-OP) included 1000 hypertensive inpatients from 29 Departments throughout Italy. Demographic, clinical data, blood pressure and the presence of comorbidities were recorded at baseline. Factors associated with OH were assessed in multiple logistic regression analysis.

RESULTS

The prevalence of OH was 25.1%. Factors independently associated with OH included disturbances of consciousness (RR 1.56, 95%CI 1.10-2.20; p = 0.01), Parkinson's disease (RR 2.30, 95%CI 1.47-3.59; p = 0.0002), type-1 diabetes (RR 1.72, 95%CI 1.05-2.80; p = 0.03), respiratory comorbidities/diseases (RR 1.32, 95%CI 1.02-1.70; p = 0.04), ischemic heart disease (IHD) (RR 1.20, 95%CI 1.01-1.43; p = 0.04) and α1-adrenergic receptor blockers use (RR 1.32, 95%CI 1.03-1.69; p = 0.03).

CONCLUSIONS

These real-world data indicate considerable prevalence of OH in hypertensive inpatients and confirm the association between OH and several common comorbidities as well as with use of α1-adrenergic receptor blockers.

CLINICAL TRIAL REGISTRATION

NCT05247060.

MeSH

Adrenergic Agents, Comorbidity, Blood, Internal Medicine, Blood Pressure, Receptors, Adrenergic, Hypotension, Orthostatic, Prevalence, Hypotension