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Publications

Journal Article Review Epublish 1 citation

PubMed: 42484259 DOI: 10.1590/0037-8682-0563-2025

The Landscape of Malaria in a Five-Decade Institution in the State of Amazonas: Historical Trends, Scientific Contributions, and Research Priorities.

Rev Soc Bras Med Trop 59(suppl 1):e05632025

Authors: Anne Cristine Gomes de Almeida, Camila Fabbri, Marcelo Augusto Mota Brito, José Diego Brito-Sousa, Fernando Almeida-Val, Joabi Rocha do Nascimento, Flor Ernestina Martinez-Espinosa, Patrike Machado Barbosa, Elder Augusto Guimaraes Figueira, Myrna Barata Machado, Vanderson de Souza Sampaio, Stefanie Costa Pinto Lopes, Wuelton Marcelo Monteiro, Marcus Vinicius Guimaraes de Lacerda, Gisely Cardoso de Melo

Affiliations

  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brasil. Universidade do Estado do Amazonas, Manaus, AM, Brasil.
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brasil.
  • Universidade Federal do Amazonas, Manaus, AM, Brasil.
  • Fundação Oswaldo Cruz Amazônia, Instituto Leônidas & Maria Deane, Manaus, AM, Brasil.
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brasil. Secretaria Municipal de Saúde, Manaus, AM, Brasil.
  • Secretaria Municipal de Saúde, Manaus, AM, Brasil.
  • Universidade do Estado do Amazonas, Manaus, AM, Brasil.
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brasil. Fundação Oswaldo Cruz Amazônia, Instituto Leônidas & Maria Deane, Manaus, AM, Brasil.
  • Fundação De Vigilância Em Saúde Do Amazonas - Drª Rosemary Costa Pinto, Manaus, AM, Brasil.
  • Instituto Todos pela Saúde, São Paulo, SP, Brasil.
  • Duke University, Duke Global Health Institute, Durham, USA.

Abstract

Malaria continues to be a major public health issue in the Brazilian Amazon, with the state of Amazonas accounting for approximately 40% of all national cases. The region presents diverse epidemiological scenarios and different infrastructure conditions, which hinder the implementation of diagnostic, treatment, management, and control strategies. Through dedicated control, surveillance and research initiatives, considerable progress has been made in reducing the incidence of cases, hospitalizations and deaths attributed to the two endemic protozoan species, Plasmodium falciparum and Plasmodium vivax. This article provides an overview of the key research and surveillance endeavors undertaken in the state of Amazonas. These efforts aim to achieve the objectives outlined in the national malaria elimination plan, enhance the understanding of the disease's pathophysiology and associated comorbidities, and leverage the advances and contributions of research groups within the state, which are focused on comprehending vector behavior and developing effective control strategies, creating more efficient diagnostic tools and researching and developing safe and effective drugs for treatment, relapse prevention and the elimination of transmission reservoirs.

MeSH

Malaria, Research, Therapeutics