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Journal Article Multicenter Study Observational Study Ppublish 3 citations

PubMed: 42489582 DOI: 10.1080/00015385.2026.2706281

Epidemiology and clinical features of acute coronary syndrome patients in selected hospitals in Greece: the CALLINICUS-Hellas registry.

Acta Cardiol 81(8):947-956

Authors: Demosthenes Panagiotakos, Donatos Tsamoulis, Vasileios Bouratzis, Ioannis Leventis, Charalampos Kalantzis, Dimitrios Tasoulas, Petros Kalogeras, Belkis Malkots, Stylianos Daios, Georgios Zormpas, Despina Benetou, Andriani Nikolaou, Andreas Ntalaoutis, Alexandros Sianis, Sofia Xanthopoulou, Zinovia Tsantikidi, Anastasios Papoutsoglou, Stylianos Rallidis, Pantelis Gounopoulos, Evagelos Zacharis, Konstantinos Kostopoulos, Sotirios Patsilinakos, Athanasios Trikas, Christodoulos Papadopoulos, Antonios Ziakas, Kimon Stamatelopoulos, Katerina Naka, Dimitrios Tziakas, Ioannis Skoularigis, Charalambos Vlachopoulos, Loukianos S Rallidis

Affiliations

  • 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital ATTIKON, Athens, Greece.
  • School of Health Sciences and Education, Harokopio University, Athens, Greece.
  • Cardiology Department, Thriasio General Hospital, Elefsina, Greece.
  • Second Department of Cardiology, University of Ioannina, Ioannina, Greece.
  • Department of Cardiology, University of Thessaly, Larissa, Greece.
  • 1st Department of Cardiology, Medical School, National and Kapodistrian, University of Athens, Hippokration Hospital, Athens, Greece.
  • 2nd Department of Cardiology, General Hospital of Nikea, Piraeus, Greece.
  • Cardiology Department, Medical School, Democritus University of Thrace, Dragana, Alexandroupolis, Greece.
  • 1st Department of Cardiology, Aristotle University of Thessaloniki, AHEPA, Thessaloniki, Greece.
  • 3rd Cardiology Department, Hippokration University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Cardiology Department, Evangelismos General Hospital, Athens, Greece.
  • 1st Department of Cardiology, General Hospital of Nikea, Piraeus, Greece.
  • Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
  • Cardiology Department, G. Papanicolaou Hospital, Thessaloniki, Greece.
  • Department of Cardiology, Konstantopoulio General Hospital, Nea Ionia, Athens, Greece.
  • Department of Cardiology, University of Patras, Patras, Greece.
  • Cardiology Department, University of Crete, Crete, Greece.

Abstract

BACKGROUND

the aim of this study is to evaluate features of acute coronary syndrome (ACS) patients, in Greece, using information from a nationwide registry, the Clinical events and Adherence to Lipid LowerINg therapy In aCUte coronary Syndrome (CALLINICUS)-Hellas registry.

METHODS

CALLINICUS-Hellas Registry is an ongoing, national, multicentre observational registry that aims to evaluate features and incidence of ACS patients in Greece. From January 2022 to December 2025, 2,661 consecutive ACS patients (2,151 males, 60 ± 11 years, 510 females, 63 ± 11 years) were enrolled in the selected collaborating cardiology clinics (15-55% participation rate). Four-point Major Adverse Cardiovascular Event (MACE) including cardiovascular death, myocardial infarction (ST-elevation myocardial infarction [STEMI] and non-STEMI [NSTEMI]), ischaemic stroke and unstable angina (UA) requiring hospitalisation was the outcome of interest at 6-months follow-up.

RESULTS

The most common ACS manifestation was NSTEMI (48%) in both sexes, followed by STEMI (37.4%) and UA (13.1%). The male-to-female ratio was approximately 4-to-1. The sex ratio favours males before age 60 years but shifts towards females thereafter. The mean age of ACS was 60 years in males, and 63 years in females. Almost 1 in 4 male and 1 in 6 female ACS patients had a previous cardiovascular event. At 6-months follow-up of 2,068 patients, MACE was observed in 120 patients (5.8%), and the most common manifestation was NSTEMI followed by UA.

CONCLUSIONS

By addressing the lack of recent registry data, the present study provides an updated description of the demographic, lifestyle, clinical, and healthcare characteristics of ACS patients treated in selected Greek hospitals, offering contemporary insights that may inform future research and healthcare planning.

MeSH

Registries, Epidemiology, Myocardial Infarction, Acute Coronary Syndrome, St Elevation Myocardial Infarction, Sex