System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Ahead of print

PubMed: 42530452 DOI: 10.1097/IAE.0000000000004949

Clinical variations and outcomes of central serous chorioretinopathy in Black and White patients: MICRoN report-16.

Retina

Authors: Niroj Kumar Sahoo, Nasiq Hasan, Bita Momenaei, Roselind Ni, Sunir Garg, Giulia Gregori, Marco Lupidi, Jessica Cao, Charles C Wykoff, Priya Shah, Panisa Singhanetr, Elizabeth Rossin, Carol Villafuerte-Trisolini, Glenn Yiu, Halit Winter, Manjot K Gill, Andrea Coletto, Mohamed El Barkani, Elodie Bousquet, Lorenzo Ferro Desideri, Felicia Hertkorn, Marion R Munk, Jay Wang, Rahul N Khurana, Yusuf Ashfaq, Zachary Kroeger, Maurizio Battaglia Parodi, Gabriele Piccoli, Stela Vujosevic, Carmen Antía Rodríguez-Fernández, Luis Arias Barquet, Kent Small, Rufino Silva, Luiz H Lima, Adrian T Fung, Lihteh Wu, Jay Chhablani

Affiliations

  • University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Philadelphia, PA, USA.
  • Department of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
  • Retina Consultants of Texas, Houston, Texas.
  • Harvard Medical School Department of Ophthalmology within Massachusetts Eye and Ear (MEE), Boston, MA.
  • University of California Davis, Davis, California, United States.
  • Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Department of Ophthalmology, Paris Cité University, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Inselspital, University Hospital Bern, Bern, Switzerland.
  • Augenarzt Praxisgemeinschaft Gutblick, Pfäffikon, Switzerland.
  • Northern California Retina Vitreous Associates, Mountain View, California.
  • Casey Eye Institute at Oregon Health and Science University, 515 SW Campus Dr. Portland, OR.
  • Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Eye Clinic IRCCS MultiMedica, Milan, Italy.
  • Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
  • Department of Ophthalmology, Hospital Universitari de Bellvitge, Carrer de La Feixa Llarga, S/N, 08907, L'Hospitalet de Llobregat, Catalunya, Spain.
  • Macula and Retina Institute, Glendale and Los Angeles, CA.
  • Molecular Insight Research Foundation, Glendale and Los Angeles, CA.
  • Faculty of Medicine, University of Coimbra,Coimbra, Portugal.
  • Ophthalmology Department. Coimbra University Hospital. ULS Coimbra. Portugal.
  • Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
  • Department of Ophthalmology, Federal University of São Paulo/Paulista School of Medicine, São Paulo, Brazil.
  • Save Sight Institute, Specialty of Clinical Ophthalmology and Eye Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Department of Ophthalmology, Westmead Hospital, Sydney, New South Wales, Australia.
  • Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
  • Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China.
  • Asociados de Macula Vitreo y Retina de Costa Rica, San José, Costa Rica.
  • University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Abstract

PURPOSE

To compare baseline characteristics and outcomes of central serous chorioretinopathy (CSCR) between people who identify as Black and those who identify as White.

METHODS

This retrospective, multicenter study from the MICRoN study group, included Black and White patients with CSCR. Demographic information and multimodal imaging parameters were analyzed and compared in the two groups. Regression models were used to identify factors affecting visual outcomes, anatomical changes, and disease recurrence/persistence.

RESULTS

We included a total of 450 patients (312 males and 138 females), of whom 100 were Black patients, and 350 were White patients. Black patients were significantly older (51.9 versus 48.8 years, p=0.03) but had shorter symptom duration at presentation (1 versus 3 months, p=0.003). They demonstrated worse baseline visual acuity (0.3±0.3 versus 0.2±0.2 logMAR, p<0.001), greater retinal detachment height (157.9 versus 107.5 μm, p=0.002), and more frequent peripapillary retinal pigment epithelium changes (27% versus 9.4%, p<0.001). During a median follow-up of 24 months (IQR 10 to 60 months), White patients experienced significantly higher rates of disease recurrence (35.7% versus 19%, p=0.002), persistent subretinal fluid (13.1% versus 4%, p=0.01), and macular neovascularization development (21.1% versus 4%, p<0.001). Multivariable regression confirmed that Black patients were associated with reduced recurrence risk (OR 0.52, p=0.03).

CONCLUSIONS

Despite presenting with more severe morphological changes and worse initial vision, Black patients demonstrate substantially lower rates of recurrences and sequelae, suggesting biological differences in disease pathophysiology.

MeSH

Central Serous Chorioretinopathy, Retinal Diseases, Retinaldehyde, Vitreous Body