Journal Article Review Ppublish
PubMed: 42538765 DOI: 10.1155/bmri/2455800
Metabolomic Discoveries for Traditional Chinese Medicine Efficacy in Alzheimer's Disease.
Biomed Res Int 2026(1):e2455800
Authors: Huimin Sun, Dongxuan Huang, Fang Yang, Pengfei Zhang, Dexin Yang, Changchun Zeng
Affiliations
- Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China, glyy.org.
- Department of Respiratory Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China, glyy.org.
- Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen Longhua District Key Laboratory for Diagnosis and Treatment of Chronic Kidney Disease, Shenzhen, Guangdong, China, glyy.org.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and behavioral alterations. However, the complex etiology and pathogenesis of AD have thus far precluded the development of satisfactory therapeutic agents. Traditional Chinese medicine (TCM) has garnered increasing recognition for its potential in AD management due to its multicomponent, multitarget therapeutic strategy. Metabolomics, an advanced analytical methodology for investigating metabolic alterations in biological systems, has yielded significant insights into both the therapeutic efficacy and mechanistic underpinnings of TCM interventions for AD. This review synthesizes recent metabolomic findings associated with TCM approaches to AD treatment, identifying key metabolic pathways across diverse biological specimens, including brain tissue, blood, urine, and feces. Through systematic elucidation of these metabolic networks, metabolomics offers substantial potential to facilitate the advancement of TCM-derived therapeutics for AD, potentially enhancing global patient outcomes.
MeSH
Alzheimer Disease, Biomedical Research, Metabolomics, Medicine, Chinese Traditional, Therapeutics