Case Reports Journal Article Epublish
PubMed: 42548379 DOI: 10.1016/j.chpulm.2025.100198
A 48-Year-Old Woman With a History of Severe Asthma and Bilateral Minute Pulmonary Nodules.
CHEST Pulm 4(1):100198
Authors: Benjamin Bottet, Nicolas Piton, Hugo Couturier, Matthieu De Meyere, Jean-Marc Baste
Affiliations
- Department of General and Thoracic Surgery, CHU Rouen, Université de Rouen Normandie, Rouen, France.
- Department of Pathology, CHU Rouen, Université de Rouen Normandie, Rouen, France.
- Inserm U1245, Université de Rouen Normandie, Rouen, France.
- Department of Pneumology, CHU Rouen, Université de Rouen Normandie, Rouen, France.
- Department of Radiology, CHU Rouen, Université de Rouen Normandie, Rouen, France.
Abstract
A 48-year-old woman was referred to a thoracic surgeon for lung biopsies because of the presence of widespread bilateral minute pulmonary nodules. She had been followed up and treated for nonallergic asthma since 27 years of age and sleep apnea syndrome. She was treated with high-dose inhaled corticosteroids combined with long-acting β-agonists and anticholinergic bronchodilators. For 4 years, she experienced > 3 asthma exacerbations related to air pollution and respiratory infections that required oral corticosteroid therapy. She had never smoked and kept domestic birds and rabbits for several years. She described an increase in respiratory symptoms when handling hay. Given the severity of the symptoms, her outpatient pulmonologist proposed introducing a new treatment with biologic therapy for the severe asthma. However, before initiation of therapy, a CT scan was performed for further evaluation.
MeSH
Adrenal Cortex Hormones, Signs And Symptoms, Sleep Apnea Syndromes, Therapeutics, Asthma, History