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Publications

Journal Article Ahead of print

PubMed: 42557778 DOI: 10.1002/hed.70423

Head and Neck Verrucous Carcinoma: A European Multicenter Retrospective Study.

Head Neck

Authors: Anne-Sophie Schrooyen, Luigi Angelo Vaira, Paolo Boscolo-Rizzo, Aina Brunet, Antonio Marí, Alberto Maria Saibene, Florent Carsuzaa, Linda Spinato, Alexandra Rodriguez, Stephane Hans, Antonino Maniaci, Carlos M Chiesa-Estomba, Giovanni Briganti, Dider Dequanter, Jerome R Lechien

Affiliations

  • Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, Brussels, Belgium.
  • Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Maxillofacial Surgery Operative Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
  • Department of Neuroscience, Section of Otolaryngology, Treviso University Hospital, University of Padova, Treviso, Italy.
  • Department of Otorhinolaryngology Head and Neck Surgery, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, Barcelona, Spain.
  • Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France. Department of Maxillofacial Surgery, Ciutat Sanitària Universitària de Bellvitge, L'Hospitalet de Ll, Barcelona, Spain.
  • Otorhinolaryngology Unit, Department of Health Sciences, Santi Paolo e Carlo Hospital, University of Milan, Milan, Italy.
  • Department of Head and Neck Surgery, Poitiers University Hospital, Poitiers, France.
  • Department of Otorhinolaryngology, CHU Brugmann, Brussels, Belgium.
  • Department of Otolaryngology-Head Neck Surgery, Foch Hospital, UFR Simone Veil, University Versailles Saint-Quentin-en Yvelines (University Paris Saclay), Paris, France.
  • Department of Medicine and Surgery, Enna Kore University, Enna, Italy.
  • Department of Otorhinolaryngology, San Sebastian University Hospital, San Sebastian, Spain.
  • Department of Neuropsychiatry and Computational Medicine, University of Mons, Mons, Belgium.
  • Department of Surgery, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.

Abstract

BACKGROUND

We characterized oncological outcomes of head and neck verrucous carcinomas (HNVC) and explored treatment-associated outcomes.

METHODS

Medical records of 106 HNVC patients (1994-2024) were reviewed, analyzing clinical history, tumor characteristics, treatment modality, and outcomes.

RESULTS

Among 106 patients, 101 underwent surgery. Five-year overall survival and recurrence-free survival were 82.2% and 85.3%, respectively. Cox regression identified age ≥ 65 years as significantly increasing recurrence risk (HR = 5.989; 95% CI 2.02-17.77), while tobacco consumption decreased risk (HR = 0.309; 95% CI 0.12-0.81). Clinical T stage influenced recurrence: cT2 (HR = 0.22), cT3 (HR = 1.366), cT4 (HR = 1.525). Compared with local resection, partial organ resection (HR = 0.841) and total organ resection (HR = 0.501) showed lower recurrence rates.

CONCLUSION

HNVC demonstrates excellent five-year survival. Surgery remains the primary treatment, with wider resections significantly reducing recurrence risk, emphasizing the importance of achieving clear margins for durable local control.

MeSH

Carcinoma, Verrucous, Retrospective Studies, Neoplasms, Otolaryngology, Therapeutics