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Publications

Journal Article Multicenter Study Ppublish

PubMed: 42621847 DOI: 10.1093/ageing/afag245

Improvement of frailty and prefrailty in older cancer survivors: a 6-month home-based pilot study.

Age Ageing 55(8)

Authors: Sabine Drevet, Mahugnon-Antonin Agbogbo, Abdallah Ghaith, Matthias Chardon, Michel Guinot, Marie Coudurier, Stephane Doutreleau, Sophie Lumale, Noé Musso, Pascal Petit, Clara Lopez, Galina Penkov, Emma El Mouzdahir, Stéphane Mouret, Evelyne Liuu, Nicolas Vuillerme, Patrice Flore, Gaëtan Gavazzi

Affiliations

  • Inserm, Sorbonne Public Health Institute, Equipe PEPITES, Sorbonne Université, Paris, France. Université Grenoble Alpes, CNRS, Grenoble INP, LIG, 38000 Grenoble, France, Institute of Engineering Université Grenoble Alpes, France. Clinic of Geriatric Medicine Department, Grenoble Alpes University Hospital, Grenoble, France.
  • Université Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, Grenoble, France.
  • Université Grenoble Alpes, CNRS, Grenoble INP, LIG, 38000 Grenoble, France, Institute of Engineering Université Grenoble Alpes, France.
  • Clinic of Geriatric Medicine Department, Grenoble Alpes University Hospital, Grenoble, France.
  • Clinique Mutualiste des Eaux-Claires-Groupement Hospitalier Mutualiste, Grenoble, France.
  • Service de Dermatologie, Allergologie & Photobiologie, Grenoble Alpes University Hospital, Grenoble, France.
  • Department of Geriatrics, Poitiers University Hospital, Poitiers, France.
  • Inserm, Clinical Investigation Center CIC 1402, University of Poitiers, Poitiers, France.

Abstract

BACKGROUND

Frailty affects 42% of older patients with cancer and is a predictor of cancer recurrence and mortality. Its impact on older cancer survivors has not yet been extensively studied.

OBJECTIVE

Assess the impact of a multicomponent home-based intervention on frailty prevalence in older adults in remission from cancer.

DESIGN

Bicentric before-and-after non-randomised intervention study (NCT04746768).

SETTING

Community-dwelling.

SUBJECTS

Patients ≥70 years old in remission from cancer who met at least one criterion for the Fried phenotype.

METHODS

A 6-month multicomponent home-based intervention was performed combining supervised exercise training and personalised nutritional support. The primary endpoint was the proportion of patients who achieved frailty or prefrailty improvement from the initial assessment (M0) to M6.

RESULTS

The mean age of the 110 participants was 77 (SD = 5) years. At baseline, 45% were frail and none were robust. Eighty-one completed the intervention (Completion Group: CG). In CG, functional, physical performance measures and the T-stage of cancer were associated with baseline frailty, while none of the other cancer-related characteristics were. Among the CG, 62% improved their frailty status at M6: 78% of frails improved, 51% of pre-frail became robust. Frailty severity decreased at M6 in 74% of participants. Vitamin D showed a group × time interaction, suggesting that frailty trajectories differed according to vitamin D status.

CONCLUSIONS

These preliminary findings suggest a potential beneficial effect of a home-based multicomponent intervention to improve frailty in community-dwelling older cancer survivors. Further controlled and adequately powered trials are required to confirm these findings.

MeSH

Exercise, Pilot Projects, Cancer Survivors, Pilots, Aging, Neoplasms, Frailty, Geriatrics