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Publications

Journal Article Ppublish

PubMed: 42637702 DOI: 10.1177/09564624261483248

Acute kidney injury among hospitalized people living with HIV.

Int J STD AIDS 37(13):1257-1259

Authors: Alice Doubinsky, Aude Theunissen, Rita Ghaleb, Marc Delforge, Maria Garjau, Nicolas Dauby

Affiliations

  • Department of Nephrology, Saint-Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
  • Department of Hematology, Hopital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
  • Department of Infectious Diseases, Saint-Pierre University Hospital, Brussels, Belgium.
  • Department of Nephrology, Saint-Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium. Department of Infectious Diseases, Saint-Pierre University Hospital, Brussels, Belgium.
  • Department of Infectious Diseases, Saint-Pierre University Hospital, Brussels, Belgium. Center for Environmental Health and Occupational Health, School of Public Health, Université Libre de Bruxelles, Brussels, Belgium.

Abstract

ObjectivesTo describe the clinical characteristics, aetiologies, severity, and short-term outcomes of acute kidney injury (AKI) among hospitalized people living with HIV in a European tertiary HIV referral center.MethodsThis cross sectional analysis included adults living with HIV who developed AKI during hospitalization at Saint-Pierre University Hospital, Brussels, between 2007 and 2016. AKI was defined according to Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria. Aetiologies, clinical characteristics, and outcomes were recorded, including intensive care unit admission, renal replacement therapy, renal recovery, chronic kidney disease (CKD) progression, in-hospital mortality, and one-year rehospitalization.ResultsAmong 206 patients with AKI, 64% had KDIGO stage 1, 21% stage 2, and 15% stage 3 AKI. Pre-renal AKI was the most frequent aetiology (45%), followed by intrinsic (25%) and mixed AKI (16%). Intensive care unit admission occurred in 36% of patients and renal repolacement therapy was required in 12%. In-hospital mortality was 16%. Among survivors, 77% achieved renal recovery, 5% progressed to chronic kidney disease, and 38% were rehospitalized within 1 year.ConclusionsAKI remains a clinically important complication among hospitalized people living with HIV, with substantial short-term morbidity and mortality. Early recognition and management of reversible causes and avoidance of nephrotoxic exposures remain important.

MeSH

Kidney Diseases, Sexually Transmitted Diseases, Mortality, Hospitalization, Hospital Mortality, Recycling, Kidney, Acquired Immunodeficiency Syndrome, Therapeutics, Renal Replacement Therapy, Acute Kidney Injury