System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Clinical Trial Protocol Ppublish

PubMed: 42700156 DOI: 10.1002/pri.70341

Effects of a Cycling-Based Aerobic Exercise Program Versus a Resistance and Neuromuscular Exercise Program on Exercise-Induced Hypoalgesia in Knee Osteoarthritis: A Study Protocol for a Randomized Clinical Trial.

Physiother Res Int 31(4):e70341

Authors: Bruno Ruocco Verengue, Lisa C Carlesso, Barbara Greco Miura, Aron Charles Barbosa da Silva, Patrícia Gabrielle Dos Santos, Almir Vieira Dibai-Filho, Cid André Fidelis-de-Paula-Gomes

Affiliations

  • Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, SĂ£o Paulo, Brazil.
  • School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
  • Postgraduate Program in Physical Education, Universidade Federal do MaranhĂ£o, SĂ£o LuĂ­s, MaranhĂ£o, Brazil.

Abstract

BACKGROUND AND PURPOSE

Exercise therapy is a core treatment for knee osteoarthritis (KOA), but the effects of different exercise modalities on endogenous pain modulation remain unclear. This trial will compare a cycling-based aerobic exercise program with a resistance and neuromuscular exercise program on exercise-induced hypoalgesia (EIH) in people with KOA and altered baseline EIH.

METHODS

This randomized, two-arm, controlled, single-blind trial will include 90 participants aged 40-75 years with symptomatic KOA, knee pain intensity of at least 3 points on the Numerical Pain Rating Scale, and altered baseline EIH. Participants will be randomized 1:1 to the Cycling-Based Aerobic Exercise Group (CAEG) or the Resistance and Neuromuscular Exercise Group (RNEG). Both groups will receive 30 supervised sessions over 10 weeks. The primary treatment effect will be the adjusted mean between-group difference in within-session change in pressure pain threshold at the most symptomatic knee, averaged across weeks 1, 4, 7, and 10. Secondary outcomes include EIH at other sites, conditioned pain modulation, pain, self-efficacy, function, performance, strength, global perceived effect, adherence, and enjoyment.

RESULTS

This trial will evaluate whether the two exercise programs differ in their capacity to elicit EIH in KOA.

DISCUSSION

This trial may clarify whether different exercise modalities produce distinct effects on acute endogenous pain modulation in KOA and may support a more precise exercise prescription for pain management.

TRIAL REGISTRATION

ClinicalTrials.gov, identifier NTC07302204.

MeSH

Exercise, Osteoarthritis, Knee, Exercise Therapy, Pain, Osteoarthritis, Aged, Therapeutics, Physical Therapy Modalities, Pain Threshold