Journal Article Epublish
PubMed: 42707541 DOI: 10.1183/23120541.01632-2025
Low appendicular muscle mass and the risk of COPD development in people with PRISm.
ERJ Open Res 12(5)
Authors: Bente Brauwers, Lies Lahousse, Guy Brusselle, Rosanne J H C G Beijers, Martijn A Spruit, Frits M E Franssen
Affiliations
- Department of Research and Development, Ciro, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands. Department of Respiratory Medicine, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
- Department of Bioanalysis, Ghent University, Ghent, Belgium.
- Departments of Epidemiology and Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
- Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
- Department of Respiratory Medicine, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
- Department of Research and Development, Ciro, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
Abstract
OBJECTIVES
Preserved ratio impaired spirometry (PRISm) is a heterogeneous condition often accompanied by respiratory symptoms and increased mortality, affecting 5-24% of the general population. However, the prevalence of low muscle mass and related clinical characteristics in PRISm remain unknown. This study aimed to: 1) determine the prevalence of low appendicular skeletal muscle index (ASMI) in individuals with PRISm compared with normal spirometry and COPD; 2) describe characteristics of persons with PRISm with low or normal ASMI; and 3) investigate whether low ASMI in PRISm is associated with COPD development.
METHODS
In the Rotterdam Study, participants were classified as PRISm, COPD, or normal spirometry. Baseline characteristics and body composition (dual-energy radiograph absorptiometry-derived ASMI) were collected. Low ASMI was defined as <7.0 kg·m -2 in males and <5.5 kg·m -2 in females. Logistic regression assessed predictors of COPD development over ∼5 years.
RESULTS
Among 5487 individuals, Low ASMI prevalence in PRISm was 8%, and was more common than in normal spirometry (4%). Among individuals with PRISm, 49% developed COPD over time. Compared to individuals with normal spirometry and normal ASMI, individuals with PRISm and low ASMI had a sevenfold higher risk of developing COPD adjusted for sex, age, and smoking.
CONCLUSION
Low ASMI was more prevalent in PRISm compared to normal spirometry. PRISm at baseline and smoking were strongly associated with COPD development, with the highest risk in individuals with PRISm and low ASMI, suggesting that low ASMI in PRISm may be a treatable trait requiring clinical attention.
MeSH
Muscles, Spirometry, Pulmonary Disease, Chronic Obstructive, Prevalence, Smoking