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Publications

Journal Article Multicenter Study Observational Study Ppublish

PubMed: 42754098 DOI: 10.1016/j.ijcard.2026.134930

Contemporary invasive management and in-hospital outcomes of acute myocardial infarction in patients with active or prior cancer: insights from the EYESHOT-2 registry.

Int J Cardiol 464:134930

Authors: Alessandra Greco, Irma Bisceglia, Maria Laura Canale, Pietro Ameri, Lucio Gonzini, Sergio Leonardi, Aldo Pietro Maggioni, Federico Nardi, Michele Massimo Gulizia, Massimo Grimaldi, Furio Colivicchi, Domenico Gabrielli, Fabrizio Oliva, Leonardo De Luca

Affiliations

  • Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Department of Cardio-Thoraco-Vascular Sciences, A.O. San Camillo-Forlanini, Roma.
  • Division of Cardiology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Lucca, Italy.
  • Cardiovascular Disease Unit, IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy; Department of Internal Medicine, University of Genova, Genova, Italy.
  • ANMCO Research Center, HCF Fondazione ANMCO per il Tuo cuore ETS, Florence, Italy.
  • Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Medical Sciences and Infective Disease, University of Pavia, Italy.
  • Division of Cardiology, Ospedale Santo Spirito, Casale Monferrato, AL, Italy.
  • Division of Cardiology, Garibaldi-Nesima Hospital, Catania, Italy.
  • Division of Cardiology, Ospedale Miulli, Acquaviva delle Fonti, BA, Italy.
  • Division of Cardiology, Presidio Ospedaliero San Filippo Neri-ASL Roma 1, Roma, Italy.
  • Department of Cardio-Thoraco-Vascular Sciences, A.O. San Camillo-Forlanini, Roma; ANMCO Research Center, HCF Fondazione ANMCO per il Tuo cuore ETS, Florence, Italy.
  • Division of Cardiology-1, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Abstract

BACKGROUND

The coexistence of cancer and acute myocardial infarction (AMI) is increasingly common, yet contemporary real-world evidence on management and outcomes remains limited. We compared AMI characteristics, treatment, and in-hospital outcomes according to cancer status.

METHODS

We analysed EYESHOT-2, a nationwide prospective registry of consecutive patients admitted to Italian cardiac care units with confirmed STEMI or NSTEMI. Patients were classified as having active cancer, prior cancer, or no cancer. Clinical characteristics, coronary angiography, revascularization, and in-hospital outcomes were compared across groups.

RESULTS

Among 2,797 patients with cancer-status data, 98 (3.5%) had active cancer and 135 (4.8%) had prior cancer. In STEMI, PCI was performed in 95.6%, 97.1%, and 94.0% of patients with active, prior, and no cancer, respectively (p = 0.65); corresponding NSTEMI rates were 69.8%, 73.8%, and 73.3% (p = 0.84). After adjustment, cancer status was not significantly associated with non-performance of PCI in STEMI (global p = 0.42) or NSTEMI (global p = 0.78). Unadjusted in-hospital mortality did not differ significantly across groups. Major bleeding was more frequent across cancer-status groups in NSTEMI (5.7%, 4.6%, and 1.7%; p = 0.03), but not in STEMI.

CONCLUSIONS

Among AMI patients admitted to participating Italian cardiac care units, cancer status was not significantly associated with non-performance of PCI after multivariable adjustment in either STEMI or NSTEMI. Mortality and bleeding comparisons were unadjusted and limited by small cancer subgroups and few events. The findings should not be interpreted as demonstrating equivalent management or prognosis, or causal treatment effects.

MeSH

Registries, Hemorrhage, Myocardial Infarction, Neoplasms, Hospital Mortality, Cardiology, Therapeutics