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Publications

Journal Article Multicenter Study Ppublish

PubMed: 42765129 DOI: 10.1111/bju.70440

Impact of operative time on complications after PCNL in the elderly (aged ≥70 years): the Safety and Efficacy of Nephrolithotomy in Older patients undergoing PCNL (SENIOR-PCNL) study.

BJU Int 138(5):915-926

Authors: Łukasz Nowak, Wojciech Krajewski, Bhaskar Somani, Tomasz Szydełko, Vineet Gauhar, Steffi Kar Kei Yuen, Matthias Boeykens, Thomas Tailly, Ioannis Mykoniatis, Alba Sierra, Emre T Sener, Vincent De Coninck, Rifat Burak Ergul, Alberto Olivero, Lazaros Tzelves, Francesco Esperto, Angelis Peteinaris, Yuigi Yuminaga, Qi Hou, Patrick Juliebø-Jones, Arman Tsaturyan, Bartosz Małkiewicz, Agata Góral, Paulina Biesiadecka, Francisco Javier Lopez Vivo, Mantu Gupta, Juan Serna, Ziv Savin, Anastasios Anastasiadis, Dimitrios Memmos, Charlotte Slots, Rita Pages, Ceyhun Ozdemiroglu, Maria Florencia Frascheri, Rafael Carrasco Moreno, Eugenio Ventimiglia, Panagiotis Kallidonis, Evangelos Liatsikos, Otas Durutovic, Amelia Pietropaolo, Begoña Ballesta Martinez

Affiliations

  • Department of Minimally Invasive and Robotic Urology, University Centre of Excellence in Urology, Wroclaw Medical University, Wroclaw, Poland.
  • Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Department of Urology, Ng Teng Fong General Hospital, Singapore, Singapore.
  • Asian Institute of Nephrourology, AINU, Chennai, India.
  • S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
  • Department of Urology, Ghent University Hospital, Ghent, Belgium.
  • Department of Urology, AZ Maria Middelares, Ghent, Belgium.
  • Department of Urology, AZ Delta, Roeselare, Belgium.
  • First Department of Urology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Department of Urology, Hospital Clinic-University of Barcelona, Barcelona, Spain.
  • Department of Urology, Marmara University School of Medicine, Istanbul, Turkey.
  • Department of Urology, AZ Klina, Brasschaat, Belgium.
  • Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Department of Urology, Muş State Hospital, Mus, Turkey.
  • Department of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Second Department of Urology, Sismanogleio Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Department of Urology, Fondazione Policlinico Universitario Campus Bio-Medico of Rome, Rome, Italy.
  • Department of Urology, University of Patras Hospital, Patras, Greece.
  • Department of Urology, Royal Perth Hospital, Perth, Western Australia, Australia.
  • Department of Urology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, China.
  • Department of Urology, Haukeland University Hospital, Bergen, Norway.
  • Department of Urology, Yerevan State Medical University, Yerevan, Armenia.
  • Department of Urology, Erebouni Medical Center, Yerevan, Armenia.
  • Department of Urology, University Hospital del Vinalopó, Alicante, Spain.
  • Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Clinic of Urology, University Clinical Centre of Serbia, Belgrade, Serbia.

Abstract

OBJECTIVES

To evaluate the association between operative time (OT) and postoperative complications after percutaneous nephrolithotomy (PCNL) in elderly patients, and to identify a clinically meaningful OT threshold for risk stratification.

PATIENTS AND METHODS

A retrospective international multicentre study was performed including patients aged ≥70 years who underwent PCNL between January 2014 and February 2025 across 21 centres in 15 countries. Postoperative complications within 30 days were analysed as overall, major, and infectious events. The optimal OT threshold was determined using receiver operating characteristic (ROC) analysis, whereas the association between OT and postoperative outcomes was evaluated using multivariable logistic regression and adjusted restricted cubic spline models.

RESULTS

Among 716 patients, 120 (16.8%) developed postoperative complications; 49 (6.8%) had major and 49 (6.8%) infectious complications. ROC analysis identified a common OT threshold around 95 min. An OT ≥95 min was independently associated with overall complications (odds ratio [OR] 3.37, 95% confidence interval [CI] 2.16-5.26), major complications (OR 2.63, 95% CI 1.35-5.10), and infectious complications (OR 3.79, 95% CI 1.90-7.57). The highest discriminative performance was observed for infectious complications (multivariable model area under the curve 0.77). Restricted cubic spline analysis confirmed significant non-linear associations between OT and all outcomes, with a steeper increase in adjusted complication probability beyond approximately 90-100 min. Non-papillary puncture was independently associated with all complication types, while positive preoperative urine culture predicted infectious complications.

CONCLUSIONS

In elderly patients undergoing PCNL, prolonged OT was independently associated with higher odds of overall, major, and infectious postoperative complications. The relationship was non-linear, with a clinically relevant threshold around 95 min, supporting OT as a practical intraoperative marker for risk stratification and procedural planning.

MeSH

Safety, Aged, Operative Time, Postoperative Complications