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Publications

Case Reports Journal Article Epublish

PubMed: 42769847 DOI: 10.1093/jscr/rjag831

Surgical management of gingival plasma cell granuloma with histopathological and immunohistochemical confirmation through CD138 and kappa/lambda polyclonally: a case report.

J Surg Case Rep 2026(9):rjag831

Authors: Mario Alberto Alarcón-Sánchez, Eder Javier Martínez-González, Gustavo Eder González-Alvarez, Enrique Felicchi Olivos-Navarro, Miguel Angel Robles-García, Lilibeth-Stephania Escoto-Vasquez, Artak Heboyan, Sarah Monserrat Lomelí-Martínez

Affiliations

  • Molecular Biology and Medicine Program, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara 44340, Jalisco, Mexico.
  • Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Guadalajara 44340, Jalisco, Mexico.
  • Department of Medical and Life Sciences, La Ciénega University Center, University of Guadalajara (CUCIENEGA-UdeG), Ocotlán 47810, Jalisco, Mexico.
  • Faculty of Dentistry, Universidad Tecnológica de México (UNITEC), Mexico City 11320, Mexico.
  • Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, India.
  • Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. Koryun 2, Yerevan 0025, Armenia.
  • Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, North Karegar St, Tehran, Iran.

Abstract

Plasma cell granuloma (PCG) is a benign inflammatory lesion of reactive origin that is rarely found in the oral cavity. Accurate recognition is essential to differentiate it from malignant lesions and avoid overtreatment or unnecessary radical resections. We present the case of a 26-year-old female with no systemic history who presented with an asymptomatic, firm, erythematous gingival mass in the right upper posterior sextant. The lesion was associated with subgingival dental calculus and a deep carious lesion involving the first premolar and first molar. Treatment included complete surgical excision, extraction of both teeth, and bone curettage. Histopathological examination confirmed PCG, while immunohistochemistry showed CD138 positivity (70%) and polyclonal Kappa/Lambda expression, excluding monoclonal neoplastic restriction. At the 2-month follow-up, healing was satisfactory without recurrence. Histopathological and immunohistochemical evaluation provides a definitive diagnosis, and conservative surgical management is curative.

MeSH

Cells, Granuloma, Molar, Immunohistochemistry, Plasma Cells, Granuloma, Plasma Cell, Plasma