Journal Article Epublish
PubMed: 42794691 DOI: 10.3390/ijms27188264
Chemerin and Arterial Stiffness in the Brisighella Heart Study: A Residual-Based Discordance Analysis.
Int J Mol Sci 27(18)
Authors: Federica Fogacci, Sergio D'Addato, Patrycja Anna Glogowski, Mirko Ragazzini, Alessandro Ciocia, Claudio Borghi, Arrigo Francesco Giuseppe Cicero, The Brisighella Heart Study Group
Affiliations
- Hypertension and Cardiovascular Risk Factors Research Centre, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.
- Department of Medical Pharmacology, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey.
- Cardiovascular Medicine Unit, IRCCS AOU BO, 40126 Bologna, Italy.
- Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy.
Abstract
Chemerin is a multifunctional adipokine involved in metabolic regulation, inflammation, and vascular homeostasis, but its relationship with arterial stiffness remains uncertain. We investigated the association between circulating chemerin and carotid-femoral pulse wave velocity (cfPWV) and explored individual chemerin-PWV discordance in participants from the Brisighella Heart Study (n = 1304). Multivariable linear regression was adjusted for age, sex, body mass index, mean arterial pressure, resting heart rate, current smoking, and estimated glomerular filtration rate. Chemerin was correlated with cfPWV in unadjusted analysis (Spearman's ρ = 0.073; p = 0.009). After adjustment, each one-standard-deviation increase in chemerin was associated with a nonsignificant 0.093 m/s higher cfPWV (95% confidence interval, -0.026 to 0.212; p = 0.126). Residual-based classification identified 132 participants with higher-than-expected chemerin and lower-than-expected cfPWV and 151 with higher-than-expected values of both measures. No investigated factor remained associated with membership in the former group after false-discovery-rate correction. Cross-fitting showed 95.6% agreement in phenotype classification. Circulating chemerin was not independently associated with central arterial stiffness, while residual analysis revealed stable but clinically unvalidated patterns of chemerin-cfPWV discordance.
MeSH
Heart, Classification, Adipokines