Journal Article Epublish
PubMed: 42820306 DOI: 10.1172/JCI204085
Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling.
J Clin Invest 136(19)
Authors: Miki Kamiyama, Jingjing Shi, Lorna Rinck, Yanzhu Lin, Yifang Mao, Xiaowen Zhang, Ashik Ahmed Abdul Pari, Stephanie F Preuss, Marlene Hoffarth, Gladys Hofsetz, Yuxi Di, Asmaa Zahran, Carleen Spegg, Maria Riedel, Donato Inverso, Roxana Ola, Junhao Hu, Kari Alitalo, Hellmut G Augustin, Mahak Singhal
Affiliations
- European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
- German Cancer Research Center, Heidelberg, Germany.
- Helmholtz Institute for Translational AngioCardioScience, Max Delbrück Center, Heidelberg University, Heidelberg, Germany.
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
- Wihuri Research Institute, University of Helsinki, Helsinki, Finland.
Abstract
Ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental vascular programs.