Journal Article Epublish
PubMed: 42841043 DOI: 10.1016/j.isci.2026.117659
Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.
iScience 29(10):117659
Authors: Teryn D Johnson, Bobby Mohan, Harvey Huang, Justin Cramer, Cornelia Drees, Matthew Hoerth, Amy Crepeau, Joseph Drazkowski, Katherine Noe, Leslie Baxter, Amir A Mbonde, Christopher Harris, Nuri Ince, Kai Miller, Dora Hermes, Gregory Worrell, Jonathon J Parker
Affiliations
- Department of Neurosurgery, Mayo Clinic, Phoenix, AZ, USA.
- Medical Scientist Training Program, Mayo Clinic, Rochester, MN, USA.
- Department of Radiology, Mayo Clinic, Phoenix, AZ, USA.
- Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
- Department of Psychiatry and Psychology, Mayo Clinic, Phoenix, AZ, USA.
- Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
- Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
- Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Abstract
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) can reduce seizures in patients with drug-resistant epilepsy. However, seizure freedom is rare, and there is no early response biomarker to predict long-term seizure suppression. To evaluate a candidate short-term biomarker of therapeutic response to DBS, we studied 18-min trials of ANT stimulation in patients with drug-resistant epilepsy undergoing intracranial electroencephalography. We compared a standard high-frequency periodic versus a non-periodic pulse pattern. We found that short-term ANT stimulation within the clinically used amplitude range preferentially altered the first 150 ms of anterograde ANT to anterior cingulate and superior frontal connectivity. Non-periodic ANT stimulation selectively modified early cortico-cortical evoked potentials more than periodic stimulation, and these changes were driven by the response phase. These pattern-specific changes in connectivity between the ANT and spatially restricted cortical areas suggest differing mechanisms and are a promising candidate biomarker for patients being treated with ANT-DBS.
MeSH
Epilepsy, Pharmaceutical Preparations, Brain, Biomarkers, Deep Brain Stimulation, Seizures