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Publications

Journal Article Epublish

PubMed: 42864312 DOI: 10.1038/s41398-026-04423-6

Assessing the effect of subthalamic stimulation on metaperception in obsessive-compulsive disorder.

Transl Psychiatry 16(1)

Authors: Audrey Kist, Michael Pereira, Ramla Msheik, Dorian Goueytes, Arnaud Pouchon, Stephan Chabardès, Julien Bastin, Mircea Polosan, Nathan Faivre

Affiliations

  • Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, 38000, Grenoble, France. Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000, Grenoble, France. Department of Psychiatry and Behavioral Sciences, UCSF, San Francisco, CA, USA.
  • Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000, Grenoble, France.
  • Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, 38000, Grenoble, France.
  • Department of Psychiatry, CHU Grenoble Alpes, F-38000, Grenoble, France.
  • Univ. Grenoble Alpes, CEA, LETI, Clinatec, 38000, Grenoble, France.
  • Univ. Grenoble Alpes, Inserm, Department of Neurosurgery, 38000, Grenoble, France.

Abstract

Most human studies on perceptual decision-making are correlational, and few addressed the causal role of the neural markers they identify. Here, we took the opportunity offered by deep brain stimulation to study the causal role of subthalamo-cortical networks on perceptual decision-making and perceptual monitoring. We asked participants with obsessive-compulsive disorder (OCD) treated with subthalamic stimulation to detect visual stimuli and provide confidence reports while we recorded scalp electroencephalography. Following a preregistered plan, we compared behavioural and neural results between patients off-stimulation and matched healthy controls and among patients on and off-stimulation to identify the effect of subthalamic stimulation on perceptual choices and metacognitive judgments. Our results indicate that patients off-stimulation detected visual stimuli similarly to matched healthy controls but provided poorer confidence judgments, indicative of a potential metacognitive alteration. Moreover, chronic subthalamic stimulation significantly reduced clinical symptoms, but acute stimulation changes did not impact visual detection, confidence, nor corresponding event-related potentials at the scalp level. We conclude that acute changes in subthalamic stimulation are insufficient to modify the potential metacognitive alterations observed in OCD.

MeSH

Signs And Symptoms, Obsessive-Compulsive Disorder, Psychiatry