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Publications

Journal Article Epublish

PubMed: 42904019 DOI: 10.1159/iid/adeag003

Biopsy-Confirmed Serofrequency of Celiac Disease among Patients with Disorders of Gut-Brain Interaction in Japan: A Multicenter Cross-Sectional Cohort Study.

Inflamm Intest Dis 11(1):429-435

Authors: Masaaki Higashiyama, Chie Kurihara, Akiko Shiotani, Takeshi Mizukami, Mikihiro Fujiya, Akihito Nagahara, Seiji Futagami, Hiroyuki Imaeda, Eikichi Ihara, Katsunori Iijima, Shuji Terai, Toshio Uraoka, Yasuhiro Fujiwara, Akira Andoh, Naoki Ohmiya, Hiromi Kataoka, Tadayuki Oshima, Takayuki Matsumoto, Hiroshi Nakase, Hirotake Sakuraba, Mamoru Watanabe, Kazushige Uchida, Hidekazu Suzuki, Masanao Nakamura, Yoshikazu Kinoshita, Govind K Makharia, Ryota Hokari

Affiliations

  • Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Department of Gastroenterology and Hepatology, Kawasaki Medical School, Okayama, Japan.
  • Department of Endoscopy Center, NHO Kurihama Medical and Addiction Center, Yokosuka, Japan.
  • Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.
  • Departments of Gastroenterology, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Division of Gastroenterology, Nippon Medical School, Tokyo, Japan.
  • Department of Gastroenterology, Saitama Medical University, Saitama, Japan.
  • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Department of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
  • Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Department of Medicine, Shiga University of Medical Science, Otsu, Japan.
  • Department of Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.
  • Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Department of Gastroenterology and Hepatology, Hyogo Medical University, Hyogo, Japan.
  • Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.
  • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
  • Organoid Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
  • Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Kochi, Japan.
  • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
  • Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Aichi, Japan.
  • Hyogo-prefectural Harima-Himeji General Medical Center, Himeji, Japan.
  • Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Abstract

INTRODUCTION

While celiac disease (CeD) is an emerging disease worldwide, its prevalence has traditionally been very low in Japan. However, there are no regional data available regarding CeD across Japan. In this study, we screened patients with disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS) and functional dyspepsia (FD), who were supposedly at a high risk for CeD. Subjects were enrolled from the Hokkaido area (northern Japan) to the Kyushu area (southern Japan) to determine the biopsy-confirmed serofrequency of CeD across Japan and its regional distribution.

METHODS

In this study, adult patients fulfilling the criteria for IBS or FD were recruited from the outpatient departments of 23 participating centers in Japan. Anti-tissue transglutaminase IgA (TTG) titers were determined for serological screening. Further histological studies were performed in patients with TTG levels >10 u/mL.

RESULTS

In total, 583 patients were enrolled in this study. There was only one subject with TTG >10 u/mL among the subjects with diarrhea-predominant IBS, who was histologically diagnosed with CeD of Marsh 3a. Biopsy-confirmed serofrequency was estimated to be 0.17% among DGBI in Japan. The regional distribution was not evaluated because of its rarity.

CONCLUSION

It is noteworthy that no clustering of CeD cases in Japanese patients with DGBI was observed, and the overall frequency remained extremely low across all participating centers nationwide.

MeSH

Brain, Cohort Studies, Biopsy, Celiac Disease