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Publications

Journal Article Review Ahead of print

PubMed: 42928416 DOI: 10.1007/s40292-026-00824-2

A Practical Treatment Platform Version 3.0 for Using Angiotensin Receptor Blocker-Based Single-Pill Combinations in Patients With Hypertension.

High Blood Press Cardiovasc Prev

Authors: Giuliano Tocci, Michel Burnier, Alejandro de la Sierra, Guido Grassi, Krzysztof Narkiewicz, Reinhold Kreutz, Konstantinos Tsioufis, Massimo Volpe

Affiliations

  • Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
  • Department of Hypertension and Diabetology, Medical University of GdaÅ„sk, GdaÅ„sk, Poland.
  • Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Terrassa, Spain.
  • Clinica Medica, S. Gerardo dei Tintori Hospital, University Milano-Bicocca, Monza, Italy.
  • Institute of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • First Department of Cardiology, School of Medicine, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • IRCCS San Raffaele Roma, Via di Valcannuta 250, Rome, Italy.

Abstract

Elevated blood pressure (BP) is the leading cause of cardiovascular disease and a major contributor to mortality, affecting almost one third of the adult population worldwide. Despite strong scientific evidence, guidelines and multiple therapeutic options, many patients remain undertreated or uncontrolled, largely due to poor medication adherence and medical inertia. Complexity of multi-pill regimens contributes significantly to non-adherence, whereas single-pill combinations (SPCs) improve adherence and persistence, accelerate BP control, and promote better long-term outcomes than multiple combinations. Appropriate selection of SPC in individual hypertensive patients may be a difficult though very important task for physicians. Thus, development of tools that may facilitate use of SPC in clinical practice is desirable. Among renin-angiotensin system blockers, olmesartan (OM) has demonstrated sustained efficacy, favourable tolerability, both as monotherapy and in SPCs with amlodipine and/or hydrochlorothiazide, which are available in multiple dosages. The present OM-based platform builds on earlier frameworks and incorporates guidelines' updates complemented by a systematic review of available literature. This "3.0" proposal expands patient categorization to include comorbidities or complications often overlooked in clinical practice guidelines, providing a practical, evidence-based approach to support individualized hypertension management complementing guideline recommendations.

MeSH

Hypertension, Receptors, Angiotensin, Multiple Chronic Conditions, Angiotensins, Angiotensin Receptor Antagonists, Therapeutics, Single-Pill Combination