Journal Article Epublish
PubMed: 42939278 DOI: 10.3390/brainsci16101025
Sex-Based Differences in Cognitive Performance in Patients with Cardiovascular Diseases.
Brain Sci 16(10)
Authors: Andreas G Prentakis, Christos I Fragoulis, Christos G Theleritis, Michelle M Mielke, Nikos P Smyrnis, Konstantinos P Tsioufis, Antonios M Politis
Affiliations
- Second Department of Psychiatry, National and Kapodistrian University of Athens, University General Hospital "ATTIKON", Rimini 1, Chaidari, 124 62 Athens, Greece.
- First Department of Cardiology, National and Kapodistrian University of Athens, Hippokration General Hospital, Vas. Sofias 114, 115 27 Athens, Greece.
- Department of Epidemiology and Prevention, Wake Forest University School of Medicine, 525 Vine Street, Winston-Salem, NC 27101, USA.
- First Department of Psychiatry, National and Kapodistrian University of Athens, Eginitio Hospital, Vas. Sofias 72-74, 115 28 Athens, Greece.
Abstract
Background/Objectives: Cardiovascular diseases (CVDs) share common risk factors with cognitive decline. The scope of this cross-sectional study was to evaluate sex-based differences in cognitive capacity in patients with CVDs. Methods: We evaluated cognitive performance in 246 patients with CVDs using the Montreal Cognitive Assessment (MoCA). Other risk factors, comorbidity with depression and anxiety disorders, and frailty score were evaluated, and patients were stratified by sex and age. Results: Age and hypertension were associated with lower MoCA scores for both sexes. However, diagnosis of depression, dyslipidemia, higher Body Mass Index (BMI), and fewer years of education were associated with a lower MoCA score only in female participants. No statistically significant difference was found in mean MoCA scores between male and female subjects of the same age groups. Conclusions: Sex-based differences and shared risk factors may be taken into account when evaluating cognitive performance, especially in patients with CVD.
MeSH
Depression, Cardiovascular Diseases, Cognitive Dysfunction, Sex, Risk Factors, Menopause, Geriatrics