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Publications

Journal Article Epublish

PubMed: 42948575 DOI: 10.1016/j.shj.2026.101096

The GLIDE Score: One-Year Outcomes Following Tricuspid Transcatheter Edge-to-Edge Repair.

Struct Heart 10(10):101096

Authors: Felix Rudolph, Akhil Narang, Maria I Körber, Kai P Friedrichs, Johannes Kirchner, Maria Ivannikova, Carolina Esperanca Clara Göttsche, Jan Althoff, Paul Cremer, Peter Luedike, Tanja K Rudolph, Tobias Geisler, Mohammad Kassar, Max Potratz, Tienush Rassaf, Roman Pfister, Fabien Praz, Volker Rudolph, Muhammed Gerçek, Charles J Davidson

Affiliations

  • Department of General and Interventional Cardiology/Angiology, Ruhr University Bochum, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.
  • Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Department for Internal Medicine III, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Tübingen, Germany.
  • Department of Cardiology, Inselspital, Bern, Switzerland.
  • Graduate School for Health Sciences, University of Bern, Switzerland.

Abstract

BACKGROUND

The GLIDE score is a 5-point imaging-based tool to predict residual tricuspid regurgitation (TR) after tricuspid transcatheter edge-to-edge repair (T-TEER). Lower residual TR is associated with better prognosis, but long-term associations between GLIDE score and outcomes are uncertain.

METHODS

We performed an analysis of a multinational registry of patients undergoing T-TEER for severe or greater TR from January 2017 to November 2022. GLIDE scores were assessed using preprocedural transesophageal echocardiography. The primary endpoint was a composite of all-cause mortality or heart failure hospitalization (HFH) at 1 year, and the secondary endpoints included TR grade of moderate or less at 1 year.

RESULTS

In 336 patients (81 [interquartile range 77-84] years; 44.6% male, TRI-SCORE 5 [interquartile range 4-6]), survival and HFH follow-up at 1 year was available in 90.5%. One-year mortality was 15.8%. The GLIDE score was significantly associated with the combined primary endpoint (hazard ratio: 1.20; 95% CI 1.03-1.40; p = 0.019), even after adjustment for TRI-SCORE. Freedom from death or HFH was significantly higher among patients with GLIDE scores ≤1 compared to those ≥2 (p = 0.032). Of the 251 1-year survivors, follow-up echocardiography was available in 170 (68%). The GLIDE score predicted 1-year TR severity (area under the receiver operating characteristic curve: 0.73; 95% CI 0.65-0.81), with moderate or less residual TR achieved in 80.6%, 54.9%, and 18.8% of patients with GLIDE scores of 0-1, 2-3, and ≥4, respectively.

CONCLUSIONS

The GLIDE score is associated with 1-year survival and HFH after T-TEER as well as ≤ moderate TR.

MeSH

Mortality, Echocardiography