article posted-content Ahead of print
OpenAlex: W4388662686 DOI: 10.1101/2023.11.10.566528
State-dependent alteration of respiration in a rat model of Parkinson disease
bioRxiv (Cold Spring Harbor Laboratory)
Authors: Jean Jacques Walker, Estelle Meunier, Samuel Garcia, Belkacem Messaoudi, Anne-Marie Mouly, Alexandra Veyrac, Nathalie Buonviso, Emmanuelle Courtiol
Affiliations
- Université Claude Bernard Lyon , CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U028 UMR5292, CMO, Centre Hospitalier Le Vinatier - Bâtiment 452, Neurocampus Michel Jouvet - 95 Bd Pinel - 69675 Bron Cedex – France
Abstract
Abstract Parkinson disease (PD) is the second most frequent neurodegenerative disorder. Besides major deficits in motor coordination, patients may also display sensory and cognitive impairments, which are often overlooked despite being inherently part of the PD symptomatology. Amongst those symptoms, respiration, a key mechanism involved in the regulation of multiple physiological and neuronal processes, appears to be altered. Importantly, breathing patterns are highly correlated with the animal’s behavioral states, and although respiration has been investigated in different models of PD, no study has yet taken into consideration the potential impact of behavioral state on respiration deficits in these models. To explore this variable, we first characterized the respiratory parameters in a neurotoxin-induced rat model of PD (6-OHDA) across different vigilance states: sleep, quiet waking and exploration. We noted a significantly higher respiratory frequency in 6-OHDA rats during quiet waking compared to Sham rats. A higher respiratory amplitude was also observed in 6-OHDA rats during both quiet waking and exploration. No effect of the treatment was noted during sleep. Given the relation between respiration and olfaction and the presence of olfactory deficits in PD patients, we then investigated the odor-evoked sniffing response in PD rats, using an odor habituation/cross-habituation paradigm. No substantial differences were observed in olfactory abilities between the two groups, as assessed through sniffing frequency. These results corroborate the hypothesis that respiratory impairments in 6-OHDA rats are vigilance-dependent. Our results also shed light on the importance of considering the behavioral state as an impacting factor when analyzing respiration. Highlights Specific respiratory patterns associated to different vigilance states Specific alteration of respiration during quiet waking in a rodent model of PD Preserved olfactory abilities as assessed through sniffing in a rodent model of PD
MeSH
Parkinson Disease, Respiration