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Studies

Interventional Active not recruiting

NCT04779970 on ClinicalTrials.gov

COIN-B: COntrolled Interruption of Nucleos(t)Ide Analogue Treatment in Chronic Hepatitis B Infections

Official title: COntrolled Interruption of Nucleos(t)Ide Analogue Treatment in Chronic Hepatitis B Infections

  • Sponsor: Antwerp University Hospital
  • Collaborators: Universiteit Antwerpen
  • Enrollment: 156 (Actual)
  • Study start: 2021-07-28 (Actual)
  • Primary completion: 2025-12-01 (Estimated)
  • Study completion: 2025-12-01 (Estimated)
  • Allocation: Non-Randomized
  • InterventionModel: Parallel
  • Masking: None
  • PrimaryPurpose: Treatment

Brief Summary

In this study we will prospectively stop NA in both Caucasian and non-Caucasian patients matched for gender and age, to validate the observed host and viral parameters for future roll-out of this treatment strategy.

Conditions

  • Chronic Hepatitis B

Intervention / Treatment

  • Other: Cessation of ongoing treatment

Primary Outcome Measures

  • Viral control (72 weeks)
    Number of participants with viral control after treatment cessation

Countries

Belgium

Locations and Investigators

  • Hopital Erasme, Anderlecht, Belgium
  • UZ Brussel, Jette, Belgium
    • Hendrik, Reynaert
  • Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe, Belgium
    • Peter, Stärkel
  • UZ Leuven, Leuven, Belgium
    • Jef, Verbeek
  • Vitaz, Sint-Niklaas, Belgium
    • Wim, Verlinden
  • Sante et Prevoyance, Namur, Belgium
    • Pierre, Deltenre
  • Centre hospitalier universitaire de Liege, Liege, Belgium
    • Jean, Delwaide
  • Chu Brugmann, Brussels, Belgium
    • Baro, Deressa
  • Ziekenhuis Aan De Stroom, Antwerp, Belgium
    • Dirk, Sprengers
  • CHU Saint Pierre, Brussels, Belgium
    • Jean-Pierre, Mulkay
  • CHC MontLegia, Liege, Belgium
    • Boris, Bastens
  • Algemeen Ziekenhuis Delta, Roeselare, Belgium
    • Charlotte, De Vloo
  • Az St-Jan Brugge-Oostende A.V., Brugge, Belgium
    • Hans, Orlent
  • AZ Turnhout, Turnhout, Belgium
    • Guy, Van Roey
  • CHU Helora, La Louviere, Belgium
    • Marie, de Vos
  • Universitair Ziekenhuis Gent, Gent, Belgium
    • Xavier, Verhelst
  • Algemeen Ziekenhuis Klina, Brasschaat, Belgium
    • Jos, Callens
  • Algemeen Stedelijk Ziekenhuis Campus Aalst, Aalst, Belgium
    • Isabelle, Colle
  • Ziekenhuis Aan De Stroom, Antwerp, Belgium
    • Stefan, Bourgeois
  • Universitair Ziekenhuis Antwerpen, Edegem, Belgium
  • Az Maria Middelares Gent, Gent, Belgium
    • Christophe, Van Steenkiste
  • Jessa Ziekenhuis, Hasselt, Belgium
    • Filip, Janssens
  • Ziekenhuis Oost Limburg, Genk, Belgium
    • Mathieu, Struyve
  • Algemeen Ziekenhuis Groeninge, Kortrijk, Belgium
    • Christophe, George
  • Grand Hopital De Charleroi, Charleroi, Belgium
    • Sergio, Negrin-Dastis
  • Algemeen Ziekenhuis Damiaan Oostende, Ostend, Belgium
    • Mike, Cool

Study Officials