Brief Summary

Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation. It is linked to higher chances of death, a longer stay in the hospital, higher costs, and the use of more antibiotics.

Options to help prevent or treat this disease are in development and will require evaluation in future clinical trials.

The goal of POS-VAP is to build and continuously train a network of ICUs to be prepared for doing these trials, to facilitate their execution.

Conditions

• Ventilator Associated Pneumonia

Primary Outcome Measures

• Number of research sites recruiting patients (4 years)
  POS-VAP' overarching objective is to build a sustainable European clinical research network of ICUs that serves as platform to facilitate observational and randomized VAP research activities. This objective will be measured by in three ways: 1\. Total number of sites in the POS-VAP network that actively recruit patients
• Number of patients recruited in the study (4 years)
  2\. Total number of patients in the POS-VAP network per analysis population (enrolled population, VAP population and microbiologically evaluable VAP population).
• Number of studies implemented through the network (4 years)
  3\. Total number of implemented observational studies and RCTs (stratified by domain: prevention, diagnosis and treatment).

Countries

Albania, Belgium, Croatia, Czechia, France, Germany, Greece, Italy, Netherlands, Romania, Serbia, Spain, United Kingdom

Locations and Investigators

• University Hospital of Trauma, Tirana, Albania (Recruiting)
  • Silva LEKA, Dr
  • Silva Leka, Dr. (Principal Investigator)
• Cliniques Universitaires Saint-Luc UCL, Brussels, Belgium (Recruiting)
  • Marie-France DUJARDIN
  • Jean-Baptiste MESLAND, Dr (Principal Investigator)
• Universitair Ziekenhuis Gent, Ghent, Belgium (Recruiting)
  • Daisy VERMEIREN
  • Jan DE WAELE, Pr (Principal Investigator)
• Hôpital de Jolimont, La Louvière, Belgium (Recruiting)
  • Anne-Catherine GERARD
  • Isabelle BUELENS
  • Vincent HUBERLANT, Dr (Principal Investigator)
• Centre Hospitalier Universitaire de Liège, Liège, Belgium (Not yet recruiting)
  • Axelle BERTRAND
  • LAMBERMONT Bernard, Pr (Principal Investigator)
• Clinique Saint Pierre Ottignies, Ottignies-Louvain-la-Neuve, Belgium (Active not recruiting)
• Clinical Hospital Center Rijeka, Rijeka, Croatia (Recruiting)
  • Ivana ARAPOVIC
  • Nataša SKOCIBUSIC
  • Vera VLAHOVIC-PALCEVSKI, Pr (Principal Investigator)
• General Hospital "Dr. Josip Benčević" Slavonski Brod, Slavonski Brod, Croatia (Recruiting)
  • Jasminka KOPIC
  • Jasminka KOPIC, Dr (Principal Investigator)
• University Hospital for Infectious Diseases, Zagreb, Croatia (Not yet recruiting)
  • Arjana TAMBIC
  • Branimir GJURASIN, Dr (Principal Investigator)
• University Hospital Kralovske Vinohrady, Brno-Vinohrady, Czechia (Recruiting)
  • Tereza CIBULKOVA
  • Nikola BANDIKOVA
  • Frantisek DUSKA, Dr (Principal Investigator)
• University Hospital Motol, Prague, Czechia (Recruiting)
  • Eva ALJAMAL
  • Sarka SPECIANOVA
  • Jaromir VAJTER, Dr (Principal Investigator)
• Centre Hospitalier William Morey, Chalon-sur-Saône, France (Recruiting)
  • Claudine DESBROSSES
  • Thomas MALDINEY, Dr (Principal Investigator)
• Centre Hospitalier Universitaire Dijon Bourgogne, Dijon, France (Recruiting)
  • Clotilde GRANGE
  • Jean Pierre QUENOT, Pr (Principal Investigator)
• Centre Hospitalier de Le Mans, Le Mans, France (Recruiting)
  • Marie Helene LEROYER
  • Cedric DARREAU, Dr (Principal Investigator)
• Centre Hospitalier Régional Universitaire de Lille, Lille, France (Recruiting)
  • Amelie CERF
  • Saad NSEIR, Pr (Principal Investigator)
• Centre Hospitalier Universitaire Dupuytren of Limoges, Limoges, France (Recruiting)
  • Théo MERIGUET
  • Thomas DAIX, Dr (Principal Investigator)
• Centre Hospitalier Universitaire de Tours, Tours, France (Recruiting)
  • Delphine CHARTIER
  • Denis GAROT, Dr (Principal Investigator)
• University Hospital Leipzig, Leipzig, Germany (Not yet recruiting)
  • Bastian PASIEKA, dR
  • Sirak PETROS, Pr (Principal Investigator)
• University Hospital of Alexandroupolis, Alexandroupoli, Greece (Not yet recruiting)
  • Vasileios PAPAIOANNOU, Pr
  • Vasileios PAPAIOANNOU, Pr (Principal Investigator)
• Evangelismos General Hospital of Athens, Athens, Greece (Not yet recruiting)
  • Eirini DAIKOU
  • Maria THEODORAKOPOULOU
  • Anastasia KOTANIDOU, Dr (Principal Investigator)
• Sotiria Thoracic Diseases Hospital of Athens, Athens, Greece (Not yet recruiting)
  • Kostis PONTIKIS, Dr
  • Antonia KOUTSOUKOU, Pr (Principal Investigator)
• General University Hospital of Larissa, Larissa, Greece (Not yet recruiting)
  • Demosthenes
  • Demosthenes MAKRIS, Pr (Principal Investigator)
• IRCCS Ospedale Policlinico Gemelli, Roma, Italy (Not yet recruiting)
  • Valentina DI GRAVIO
  • Gennaro DE PASCALE, Dr (Principal Investigator)
• Deventer Ziekenhuis, Deventer, Netherlands (Recruiting)
  • Arriette KRUISDIJK-GERRITSEN
  • H VAN DEN OEVER, Dr (Principal Investigator)
• University Medical Center Utrecht, Utrecht, Netherlands (Recruiting)
  • Brittney VAN DER WOUDE
  • Olaf CREMER, Pr (Principal Investigator)
  • Lennie DERDE, Dr
• Central Military Emergency University Hospital Dr. Carol Davila, Bucharest, Romania (Recruiting)
  • Filomon RALUCA
  • Dan CORNECI, Pr (Principal Investigator)
• Elias University Emergency Hospital, Bucharest, Romania (Recruiting)
  • Oanamaria TUDORACHE
  • Silvius NEGOITA, Dr (Principal Investigator)
• University Clinical Center of Serbia, Belgrade, Serbia (Recruiting)
  • Biljana CAREVIC
  • Ivana RADOVANOVIC
  • Alexandra BARAC, Dr (Principal Investigator)
  • Biljana CAREVIC, Pr
• Hospital Universitario Reina Sofia, Córdoba, Spain (Recruiting)
  • Rafael LEON LOPEZ, Dr
  • Rafael LEON LOPEZ, Dr (Principal Investigator)
• Hospital Universitario Central de Asturias, Oviedo, Spain (Recruiting)
  • Lorena FORCELLEDO, Dr
  • Dolores ESCUDERO, Dr (Principal Investigator)
  • Lorena FORCELLEDO, Dr
• IMED Valencia, Burjassot, Spain (Recruiting)
  • Jose EXPOSITO OLLERO
  • Mercedes MURCIA ANAYA, Dr (Principal Investigator)
• Vall d'Hebrón University Hospital, Barcelona, Spain (Active not recruiting)
• John V Farman Intensive Care Unit, Cambridge, United Kingdom (Not yet recruiting)
  • Andrew CONWAY MORRIS, Dr
  • Andrew CONWAY MORRIS, Dr (Principal Investigator)
• Royal Infirmary of Edinburgh, Edinburgh, United Kingdom (Not yet recruiting)
  • Thomas CRAVEN, Dr
  • Thomas CRAVEN, Dr (Principal Investigator)
• Royal Victoria Infirmary, Newcastle, United Kingdom (Not yet recruiting)
  • Thomas HELLYER, Dr
  • Thomas HELLYER, Dr (Principal Investigator)