Observational Enrolling by invitation
NCT05750940 on ClinicalTrials.gov
Oxidative Skeletal Muscle Metabolism in Chronic Heart Failure Patients With and Without Iron Deficiency
- Sponsor: University Medical Center Groningen
- Enrollment: 40 (Estimated)
- Study start: 2021-10-05 (Actual)
- Primary completion: 2023-04-01 (Estimated)
- Study completion: 2023-05-01 (Estimated)
- Allocation: N/a
- InterventionModel: N/a
- Masking: None
- PrimaryPurpose: Other
Brief Summary
Observational study using in vivo noninvasive 31 phosphor magnetic resonance spectroscopy (31P MRS) to quantify the effect of iron deficiency (ID) on skeletal oxidative metabolism in patients with chronic heart failure (HF).
Conditions
- HF - Heart Failure
- Iron-deficiency
Intervention / Treatment
- Diagnostic Test: 31Phosphor Magnetic Resonance Spectroscopy
Primary Outcome Measures
-
ΔPi/PCr from baseline to maximum exercise
(During study visit, from resting baseline to maximum exercise (from start exercise upto exhaustion for a maximum timeframe of 10 minutes))
Δ ratio of inorganic phosphate/Phosphocreatinin concentrations from baseline to maximum exercise
Countries
Netherlands
Locations and Investigators
- UMCG, Groningen, Netherlands